{"id":"W2045666417","doi":"10.1172/jci22954","title":"Inhibition of adenine nucleotide translocator pore function and protection against apoptosis in vivo by an HIV protease inhibitor","year":2005,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":91,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; National Research Council Canada; University of Ottawa","funders":"Canadian Institutes of Health Research; Alzheimer Society; National Institutes of Health; Sidaction; National Institute of Allergy and Infectious Diseases; Association pour la Recherche sur le Cancer; Styrelsen för Internationellt Utvecklingssamarbete; Wellcome Trust; Heart and Stroke Foundation of Canada","keywords":"Adenine nucleotide translocator; Apoptosis; Ritonavir; Nelfinavir; In vivo; Protease; Biology; Protease inhibitor (pharmacology); Lopinavir; Pharmacology; Mitochondrial permeability transition pore; Programmed cell death; Cell biology; Biochemistry; Virology; Enzyme; Virus; Viral load","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002211168,0.0002816007,0.0003062843,0.0001937936,0.0001189869,0.0002622363,0.0002246953,0.000220656,0.0009751209],"category_scores_gemma":[0.0001998653,0.0001058389,0.0001484432,0.00009903764,0.0002123594,0.0003369171,0.00008940823,0.0006890242,0.0001663503],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001475258,"about_ca_system_score_gemma":0.00017632,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002334993,"about_ca_topic_score_gemma":0.0005097149,"domain_scores_codex":[0.9998704,0.00003535251,0.00001034843,0.000009838575,0.00002731958,0.00004668272],"domain_scores_gemma":[0.9998714,0.00003002759,0.00003717756,0.00001823386,0.00001130075,0.00003181682],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001284088,0.0004041935,0.000341456,0.00005467624,0.00001885109,0.00005937898,0.00002030672,0.0001772137,0.9892333,0.0002057702,0.0000696608,0.008131171],"study_design_scores_gemma":[0.0001595269,0.007757896,0.004939056,0.00001121055,0.00003743623,0.000309479,0.00002820068,0.001304915,0.9842163,0.0001366918,0.00109363,0.000005638905],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966986,0.001447567,0.0009318258,0.00007318098,0.00001880314,0.0000175876,0.00005589222,0.00003851173,0.0007180726],"genre_scores_gemma":[0.9969144,0.001122142,0.001018083,0.0000266823,0.00001419495,0.00001851338,0.0001403185,0.00000476916,0.0007410264],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009751209,"threshold_uncertainty_score":0.003262162,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03840242906712337,"score_gpt":0.3086819531659627,"score_spread":0.2702795240988393,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}