{"id":"W2045683975","doi":"10.1002/pbc.22298","title":"Rapamycin (sirolimus) in tuberous sclerosis associated pediatric central nervous system tumors","year":2009,"lang":"en","type":"article","venue":"Pediatric Blood & Cancer","topic":"Tuberous Sclerosis Complex Research","field":"Medicine","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"","keywords":"Tuberous sclerosis; Medicine; Sirolimus; Subependymal giant cell astrocytoma; Subependymal zone; Blood cancer; Oncology; Cancer; Glioma; Pathology; Internal medicine; Cancer research; Astrocytoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007249871,0.0006134407,0.001200828,0.001074411,0.0002147969,0.0001085044,0.0005318713,0.0003843614,0.0002557474],"category_scores_gemma":[0.0003203524,0.0005975265,0.0003517361,0.003650616,0.00006258791,0.0002260274,0.0001263136,0.001165833,0.000123536],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001095072,"about_ca_system_score_gemma":0.0009105556,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002628392,"about_ca_topic_score_gemma":0.00037623,"domain_scores_codex":[0.9937272,0.0003035567,0.001163554,0.00107114,0.001545348,0.002189217],"domain_scores_gemma":[0.9975151,0.0002262676,0.000349187,0.0007673187,0.0003283066,0.0008138182],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002996446,0.001635997,0.9851474,0.000620644,0.0001062571,0.0004051908,0.0004825488,0.000391667,0.00131386,0.0000690271,0.005237203,0.004290562],"study_design_scores_gemma":[0.006651718,0.0006882485,0.9897296,0.0002235501,0.001020664,0.0001019365,0.0001072716,0.0005648079,0.0002755873,0.00001878832,0.00004875291,0.0005690997],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9844,0.01099611,0.000009447094,0.001114804,0.0004969207,0.001336463,0.00008528897,0.0005301073,0.001030812],"genre_scores_gemma":[0.9920543,0.003179598,0.0001573378,0.0006353935,0.003294808,0.0001917935,0.00004416524,0.000113948,0.0003286456],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00781651,"threshold_uncertainty_score":0.9996476,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03120420964635116,"score_gpt":0.2733448259160918,"score_spread":0.2421406162697407,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}