{"id":"W2045759734","doi":"10.1038/labinvest.3780362","title":"Focal Adhesion Kinase Is a Key Mediator of Human Trophoblast Development","year":2001,"lang":"en","type":"article","venue":"Laboratory Investigation","topic":"Pregnancy and preeclampsia studies","field":"Medicine","cited_by":77,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; Mount Sinai Hospital; Hospital for Sick Children; Lunenfeld-Tanenbaum Research Institute; University of Toronto","funders":"","keywords":"Focal adhesion; Cytotrophoblast; Paxillin; Trophoblast; Biology; Cell biology; PTK2; Extracellular matrix; Integrin; Matrigel; Cell adhesion; MMP2; Signal transduction; Cell; Kinase; Placenta; Protein kinase A; Downregulation and upregulation; Biochemistry; Fetus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001723849,0.0001444658,0.0002516167,0.00009857146,0.000133517,0.000006583176,0.00006255089,0.0001063714,0.0001020243],"category_scores_gemma":[0.0001075357,0.0001302718,0.00003702923,0.0003741618,0.0001631989,0.00011624,0.00003265413,0.0001259959,0.00004268877],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007060865,"about_ca_system_score_gemma":0.0002696862,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001121655,"about_ca_topic_score_gemma":0.00002875649,"domain_scores_codex":[0.9988964,0.00005957736,0.000356066,0.0002101374,0.00031033,0.0001674687],"domain_scores_gemma":[0.9992356,0.00003122497,0.0001439307,0.0002202242,0.0002161837,0.0001528584],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001598575,0.000181382,0.441058,0.0004443623,0.0001261211,0.00007100845,0.01088716,0.000001820812,0.5367191,0.001092285,0.007148215,0.00211071],"study_design_scores_gemma":[0.001326813,0.000308495,0.2114228,0.000646397,0.00007246901,0.000004252797,0.0003634178,0.0000239118,0.7717289,0.000570795,0.01334465,0.0001871699],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972173,0.0008858834,0.00003568971,0.0007078481,0.000100201,0.0002367621,0.00001132936,0.00006564777,0.0007393663],"genre_scores_gemma":[0.9966047,0.00007449965,0.00196702,0.000980906,0.0001138306,0.00004300049,0.00004319526,0.00001654978,0.00015632],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2350097,"threshold_uncertainty_score":0.531233,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02787581477567682,"score_gpt":0.2677565572477428,"score_spread":0.239880742472066,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}