{"id":"W2045763593","doi":"10.1371/journal.pone.0038666","title":"Glutamate and Synaptic Plasticity Systems and Smoking Behavior: Results from a Genetic Association Study","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University of Toronto","funders":"Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior","keywords":"Candidate gene; Genotyping; Heritability; Biology; Genetics; Missing heritability problem; Single-nucleotide polymorphism; Genetic association; Population; Genome-wide association study; Nicotine; Bioinformatics; Gene; Medicine; Neuroscience; Genotype; Environmental health","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002016417,0.0007094077,0.0007390762,0.0006057734,0.0003739726,0.0005521807,0.000405732,0.0005783816,0.001951944],"category_scores_gemma":[0.004468255,0.0001843536,0.0008156691,0.001196125,0.0004974377,0.0001876378,0.0004402089,0.0004126852,0.0002387303],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002645724,"about_ca_system_score_gemma":0.0004098874,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007130255,"about_ca_topic_score_gemma":0.007773497,"domain_scores_codex":[0.9988747,0.0003810041,0.0001394971,0.0003376435,0.0002048762,0.00006218333],"domain_scores_gemma":[0.9978049,0.001041681,0.0003829268,0.0002980444,0.00028738,0.0001850308],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001870085,0.0001586079,0.9591358,0.0002247953,0.001854733,0.001510123,0.0008690653,0.0001692115,0.01792126,0.0001061561,0.0001666814,0.01601349],"study_design_scores_gemma":[0.00008579378,0.0002838344,0.9947776,0.00002584979,0.001391292,0.001450412,0.000166694,0.0003035837,0.0007801402,0.0001419412,0.0005815229,0.00001131326],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959592,0.002125816,0.0007703805,0.0002145897,0.00001160896,0.00002107451,0.0002885398,0.000008046526,0.0006006816],"genre_scores_gemma":[0.9981791,0.0008009272,0.0005243833,0.00006214157,0.00001996103,0.00001110733,0.000216504,0.000005964062,0.0001798944],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007130255,"threshold_uncertainty_score":0.0141775,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02751661060282352,"score_gpt":0.2419988935641729,"score_spread":0.2144822829613494,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}