{"id":"W2045781131","doi":"10.1006/abio.2000.4732","title":"Development of a Method for Evaluating Protein Tyrosine Phosphatase CD45 Inhibitors Using Jurkat Cell Membrane","year":2000,"lang":"en","type":"article","venue":"Analytical Biochemistry","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Jurkat cells; Protein tyrosine phosphatase; Phosphatase; Chemistry; Cell; Biochemistry; Cell membrane; Molecular biology; Plate reader; Membrane; Cell biology; Biology; T cell; Fluorescence; Enzyme; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001183231,0.001597941,0.0009109657,0.001407946,0.0007723917,0.0007716652,0.001294083,0.001027131,0.002134959],"category_scores_gemma":[0.0008091411,0.001035619,0.0007400587,0.0007386028,0.0004563092,0.0007347591,0.0006348554,0.002602981,0.002083367],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008685518,"about_ca_system_score_gemma":0.001035572,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001760224,"about_ca_topic_score_gemma":0.004511418,"domain_scores_codex":[0.9990531,0.0002217189,0.00009005854,0.0001902952,0.000296749,0.0001480585],"domain_scores_gemma":[0.9992379,0.0002768456,0.00008617098,0.0001081009,0.0002021737,0.00008892864],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003355543,0.00003876298,0.00007964158,0.00005578484,0.000009728366,0.00002367814,0.00001561387,0.00005668088,0.9959816,0.0002511167,0.00007642407,0.003377348],"study_design_scores_gemma":[0.00001272543,0.0001025033,0.0003950692,0.000008110077,0.00002396913,0.0001364191,0.00001084214,0.001671101,0.9950262,0.0001269255,0.002478122,0.000008037608],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.08225317,0.001963316,0.9070234,0.0003343389,0.0001746385,0.0009812486,0.0005567038,0.00195248,0.004760693],"genre_scores_gemma":[0.1695411,0.003242779,0.8116561,0.0002714522,0.00006075173,0.002151888,0.002070293,0.0003178945,0.01068777],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.002134959,"threshold_uncertainty_score":0.007142127,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02461541194312902,"score_gpt":0.3286466185135839,"score_spread":0.3040312065704549,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}