{"id":"W2045792217","doi":"10.1016/j.canlet.2006.10.026","title":"Anticancer activity of a ceramide analog containing a disulfide linkage","year":2006,"lang":"en","type":"article","venue":"Cancer Letters","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"","keywords":"Ceramide; Glutathione; DU145; Cytotoxic T cell; Chemistry; Biochemistry; In vitro; Apoptosis; Cancer cell; Biology; Cancer; Enzyme; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001471298,0.0002044619,0.000206503,0.0002831074,0.0001559883,0.0001559423,0.0002473937,0.0003100061,0.001460261],"category_scores_gemma":[0.0001281626,0.00008882408,0.0001525373,0.0001911331,0.0001235976,0.0001586657,0.0001255289,0.0003462457,0.0002299031],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001868554,"about_ca_system_score_gemma":0.0002107615,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006532086,"about_ca_topic_score_gemma":0.00049,"domain_scores_codex":[0.9999495,0.00001300143,0.000005189853,0.000007160883,0.000009190083,0.00001594558],"domain_scores_gemma":[0.9999514,0.00001019194,0.000006570244,0.00001097599,0.000006305936,0.00001456876],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001819655,0.0001722282,0.0002393527,0.00005137899,0.00002414955,0.0002454617,0.00001989593,0.0006448769,0.9877595,0.0003745161,0.000216564,0.008432324],"study_design_scores_gemma":[0.0001687341,0.001453676,0.0006283921,0.000003557604,0.0000316201,0.00024964,0.00001050255,0.0006585771,0.9944666,0.00004731129,0.002276028,0.00000539584],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946259,0.001281305,0.0004752034,0.0001234299,0.0000467006,0.00003291302,0.0001891486,0.00003340435,0.003192008],"genre_scores_gemma":[0.9978938,0.000550895,0.0003051542,0.00003563234,0.00001087901,0.000007317177,0.0001974661,0.000004188031,0.0009948694],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001460261,"threshold_uncertainty_score":0.004885018,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007517032394723616,"score_gpt":0.2478629419846279,"score_spread":0.2403459095899043,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}