{"id":"W2045792217","doi":"10.1016/j.canlet.2006.10.026","title":"Anticancer activity of a ceramide analog containing a disulfide linkage","year":2006,"lang":"en","type":"article","venue":"Cancer Letters","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"","keywords":"Ceramide; Glutathione; DU145; Cytotoxic T cell; Chemistry; Biochemistry; In vitro; Apoptosis; Cancer cell; Biology; Cancer; Enzyme; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001132872,0.0001282673,0.0001979928,0.00003920558,0.00004632568,0.00001415514,0.0001289534,0.00006708225,0.00002364368],"category_scores_gemma":[0.00002345677,0.0001244541,0.0001024134,0.00009547074,0.0001007403,0.000005651068,0.00004305768,0.0000821444,0.000001317485],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001922894,"about_ca_system_score_gemma":0.00005747228,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007963544,"about_ca_topic_score_gemma":0.0001137605,"domain_scores_codex":[0.9991775,0.00003577605,0.0001674174,0.0002648323,0.0001147617,0.0002397238],"domain_scores_gemma":[0.9995667,0.00001419949,0.0001140943,0.0002240381,0.00003959127,0.00004139337],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009261566,0.00001810105,0.01773378,0.00002218969,0.0000382433,0.000003335916,0.00003689358,0.0008141529,0.9783528,0.0000646605,0.001250191,0.001572985],"study_design_scores_gemma":[0.0007846499,0.00003856084,0.04623341,0.00003879787,0.00004470828,0.000002391118,0.00001743354,0.0001114766,0.9390155,0.00002228243,0.01348093,0.000209876],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919131,0.001373167,0.00549181,0.0004420638,0.0002360448,0.00009077707,0.00002938255,0.00001137133,0.0004123284],"genre_scores_gemma":[0.9973046,0.0001159801,0.0002576156,0.001339758,0.0008360105,0.00002435031,0.00002181086,0.00001935892,0.00008047896],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03933736,"threshold_uncertainty_score":0.5075091,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007517032394723616,"score_gpt":0.2478629419846279,"score_spread":0.2403459095899043,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}