{"id":"W2045828490","doi":"10.1093/nar/gkl090","title":"A TFIIB-like protein is indispensable for spliced leader RNA gene transcription in Trypanosoma brucei","year":2006,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Trypanosoma species research and implications","field":"Medicine","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; Yale University; National Institutes of Health; York University; Wellcome Trust; University of Connecticut","keywords":"Biology; Transcription factor II B; Transcription factor II A; RNA polymerase II; Genetics; Transcription (linguistics); Transcription factor II D; Transcription preinitiation complex; RNA splicing; Molecular biology; Gene; RNA polymerase; Promoter; RNA; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002245004,0.0002507714,0.0004301377,0.0008846133,0.0003743226,0.0001393505,0.0004302108,0.0003233424,0.00101797],"category_scores_gemma":[0.0002506525,0.0002343178,0.0001995182,0.001613191,0.0003969115,0.0002851078,0.00008945553,0.0009660727,0.0005232947],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006680604,"about_ca_system_score_gemma":0.0005981437,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001142703,"about_ca_topic_score_gemma":0.0002908115,"domain_scores_codex":[0.9956383,0.0001681267,0.0005650544,0.0007562054,0.001386613,0.001485725],"domain_scores_gemma":[0.9979961,0.0001360851,0.00004172913,0.0008439228,0.0006233142,0.0003588722],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007804756,0.0006171268,0.0008187043,0.0002104155,0.00003181075,0.00002820801,0.000340451,0.000002084194,0.9620005,0.002218133,0.02934334,0.003608768],"study_design_scores_gemma":[0.009312343,0.001462684,0.3476089,0.0002271689,0.00002362698,0.00007315536,0.0008535492,0.001360725,0.5015451,0.003587193,0.1335257,0.0004199091],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9684086,0.0003654445,0.0005405439,0.01212955,0.00004814045,0.004473384,0.0001097881,0.0001016764,0.01382283],"genre_scores_gemma":[0.9670553,0.00006099194,0.00337261,0.0002727238,0.0004300245,0.001420807,0.0001634164,0.00009213316,0.027132],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4604554,"threshold_uncertainty_score":0.9998952,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08395305491884679,"score_gpt":0.37178422071136,"score_spread":0.2878311657925132,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}