{"id":"W2045832601","doi":"10.1038/bcj.2013.24","title":"BET inhibition as a single or combined therapeutic approach in primary paediatric B-precursor acute lymphoblastic leukaemia","year":2013,"lang":"en","type":"article","venue":"Blood Cancer Journal","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":85,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Leukaemia and Lymphoma Research; Cancer Research UK; Genome Canada; Wellcome Trust; GlaxoSmithKline; Ontario Ministry of Research and Innovation; Pfizer; Eli Lilly and Company","keywords":"Bromodomain; Downregulation and upregulation; BET inhibitor; Cancer research; Dexamethasone; BRD4; Cytotoxic T cell; Cell cycle checkpoint; Medicine; In vitro; Cell cycle; Biology; Immunology; Epigenetics; Gene; Internal medicine; Genetics; Cancer","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001507197,0.0002850126,0.0006696472,0.0003498403,0.0001572423,0.000405148,0.0002899087,0.0002264473,0.001286946],"category_scores_gemma":[0.0001140172,0.0001260196,0.0002326431,0.0003344284,0.0002145755,0.0001819756,0.0001855558,0.0007370868,0.0003135256],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003257481,"about_ca_system_score_gemma":0.000292548,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004958488,"about_ca_topic_score_gemma":0.001938422,"domain_scores_codex":[0.999894,0.00001777627,0.000007557415,0.00001598339,0.00002768841,0.00003702989],"domain_scores_gemma":[0.9999418,0.00001190056,0.00001228816,0.000008015756,0.000005503687,0.00002054154],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002467957,0.0009843468,0.001442322,0.0003848822,0.00009814742,0.0003924205,0.0001004235,0.001219656,0.9484315,0.0005415321,0.0008685924,0.04306825],"study_design_scores_gemma":[0.001009557,0.01807932,0.02868887,0.00005209504,0.0003132275,0.003285916,0.000139237,0.002265203,0.9175075,0.0002927929,0.02833709,0.00002915077],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897982,0.006512193,0.000761138,0.0001503923,0.00006858249,0.00009019556,0.0002864595,0.00007628983,0.002256621],"genre_scores_gemma":[0.9895638,0.006523951,0.001239005,0.00007911141,0.00003592078,0.00006611715,0.0005403604,0.00002031823,0.001931385],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001286946,"threshold_uncertainty_score":0.004305303,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01032834145084928,"score_gpt":0.2323381175858695,"score_spread":0.2220097761350202,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}