{"id":"W2045877860","doi":"10.1016/j.jhep.2010.08.040","title":"Potency, safety, and pharmacokinetics of the NS3/4A protease inhibitor BI201335 in patients with chronic HCV genotype-1 infection","year":2010,"lang":"en","type":"article","venue":"Journal of Hepatology","topic":"Hepatitis C virus research","field":"Medicine","cited_by":112,"is_retracted":false,"has_abstract":false,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"Medicine; Rash; Ribavirin; Gastroenterology; Dosing; Internal medicine; Viral load; Pharmacokinetics; Pharmacology; Leukopenia; Potency; Toxicity; Immunology; Hepatitis C virus; Biology; Virus; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000363414,0.0001023603,0.00033775,0.000249768,0.00003928803,0.000005405293,0.00009397278,0.0001257595,0.0001117525],"category_scores_gemma":[0.0003004243,0.00006130041,0.00005088282,0.0002332067,0.0002207478,0.00008411012,0.00006787551,0.0008579326,0.000003768777],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001021052,"about_ca_system_score_gemma":0.0005339169,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003262806,"about_ca_topic_score_gemma":0.0008880115,"domain_scores_codex":[0.9986951,0.0001424827,0.0004774985,0.000106593,0.0003675305,0.0002108086],"domain_scores_gemma":[0.9989363,0.00005345811,0.000316077,0.0001696441,0.0004039558,0.0001205555],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001127237,0.0002317379,0.9694467,0.00008662814,0.00004167777,0.00003183246,0.00006617892,0.000005479947,0.008404203,0.00001409085,0.0001403357,0.02040395],"study_design_scores_gemma":[0.005671731,0.002233331,0.9760808,0.0001132372,0.00006485374,0.0001609834,0.000002387939,0.000244232,0.008027799,0.0000410031,0.007287226,0.00007244467],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976222,0.0001289708,0.00003008259,0.001150142,0.0003329102,0.0004893944,0.00000509731,0.000003371285,0.000237824],"genre_scores_gemma":[0.9992186,0.0002378002,0.0002602387,0.00008773847,0.000149606,0.000003703753,0.000001316745,0.00001569115,0.00002531208],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0203315,"threshold_uncertainty_score":0.3727338,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007346901921931297,"score_gpt":0.2740517144745193,"score_spread":0.266704812552588,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}