{"id":"W2045886309","doi":"10.1016/j.bbrc.2008.10.044","title":"Roles of G protein and β-arrestin in dopamine D 2 receptor-mediated ERK activation","year":2008,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa","funders":"","keywords":"Arrestin; MAPK/ERK pathway; Pertussis toxin; Cell biology; G protein; Dopamine; G protein-coupled receptor; Chemistry; Receptor; BETA (programming language); Biology; Phosphorylation; Signal transduction; Biochemistry; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000290411,0.00008720872,0.0001292517,0.00006918963,0.0001298178,0.00001014604,0.0002579515,0.0001198438,0.000009447117],"category_scores_gemma":[0.0005295099,0.00007582898,0.00002480479,0.0002446413,0.0006245478,0.000006408991,0.0003349076,0.0002323201,0.000002644459],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001055097,"about_ca_system_score_gemma":0.00005518509,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007829451,"about_ca_topic_score_gemma":0.000008986919,"domain_scores_codex":[0.9990513,0.0001591019,0.0001894167,0.0002223309,0.0001914187,0.0001864709],"domain_scores_gemma":[0.9991817,0.0001254857,0.00004083021,0.0003970777,0.0001574741,0.000097374],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006524285,0.0001773179,0.0002840383,0.00001781798,0.000007058321,2.124406e-7,0.00004335277,1.786311e-7,0.9973121,0.0006329963,0.0001367479,0.001322883],"study_design_scores_gemma":[0.000303762,0.0001903185,0.001344848,0.00005479953,0.000001260977,0.000001595479,0.00008198303,0.0002044358,0.9945601,0.0002605371,0.002904173,0.00009214891],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980173,0.0009105246,0.00004737986,0.0006349696,0.000004007831,0.0002184266,0.00001594914,0.000005693832,0.0001457781],"genre_scores_gemma":[0.9961241,0.001566786,0.001927948,0.00001412441,0.00004531987,0.00005905821,0.0001828122,0.000008708621,0.00007109301],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002767425,"threshold_uncertainty_score":0.3092216,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05433139521299541,"score_gpt":0.3248421358248343,"score_spread":0.2705107406118389,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}