{"id":"W2045887831","doi":"10.1074/jbc.m113.521666","title":"Mitochondrial Metabolism of Pyruvate Is Essential for Regulating Glucose-stimulated Insulin Secretion","year":2014,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":105,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; University of Waterloo","funders":"Canadian Institutes of Health Research","keywords":"Biology; Secretion; Mitochondrion; Insulin; Regulator; Cell biology; Carbohydrate metabolism; Glucose homeostasis; Biochemistry; Endocrinology; Insulin resistance","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002876584,0.0001131202,0.0005021072,0.00002986891,0.00003237764,0.000007605073,0.00007120008,0.0002247632,0.0003319253],"category_scores_gemma":[0.001874638,0.0000738621,0.0002679639,0.0000925647,0.0000813213,0.00003228159,0.00001800687,0.000172177,0.000001617388],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001959746,"about_ca_system_score_gemma":0.00004543621,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001254607,"about_ca_topic_score_gemma":1.079044e-8,"domain_scores_codex":[0.9989396,0.0000295995,0.0005872699,0.0001250165,0.000175227,0.0001433349],"domain_scores_gemma":[0.9986842,0.0002284075,0.0005132396,0.0001105986,0.0003366121,0.0001269041],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0012383,0.00009544746,0.0006845921,0.00009433104,0.00008764834,0.000001209249,0.00002418185,0.00002238105,0.9957705,0.00001663505,0.0004128015,0.001551979],"study_design_scores_gemma":[0.004014465,0.0003278604,0.002605747,0.0001180809,0.0001614713,0.0000290009,0.00003088807,0.00244692,0.9858586,0.0006282011,0.003698864,0.00007995154],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960144,0.0003657506,0.002442918,0.0002910376,0.0002338207,0.00009024978,0.0000101626,0.00001354745,0.0005381276],"genre_scores_gemma":[0.9934945,0.00004096832,0.004808957,0.0001809377,0.001308794,0.000002141986,0.00002678929,0.000007228896,0.0001296972],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009911943,"threshold_uncertainty_score":0.3634349,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01993277318475929,"score_gpt":0.2681969453129907,"score_spread":0.2482641721282314,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}