{"id":"W2045911618","doi":"10.1074/jbc.m115.644351","title":"The Atomic Structure of the HIV-1 gp41 Transmembrane Domain and Its Connection to the Immunogenic Membrane-proximal External Region","year":2015,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Gp41; Transmembrane domain; Transmembrane protein; Helix (gastropod); Isothermal titration calorimetry; Biophysics; Glycoprotein; Lipid bilayer fusion; Protein structure; Viral envelope; Chemistry; Biology; Membrane; Biochemistry; Antibody; Epitope; Genetics; Receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000583179,0.000186903,0.0001258856,0.0001149788,0.0003574743,0.0001918926,0.0003386448,0.0003364652,0.0004689796],"category_scores_gemma":[0.0002462157,0.0001374431,0.0001239176,0.000212223,0.000292055,0.0003418819,0.0001679545,0.0003930885,0.0001197469],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000255283,"about_ca_system_score_gemma":0.0002347586,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001158445,"about_ca_topic_score_gemma":0.0006884962,"domain_scores_codex":[0.9999731,0.000003965313,0.000001435678,0.000008364999,0.000008846178,0.000004395301],"domain_scores_gemma":[0.9999446,0.00001668072,0.00001561912,0.000009153974,0.000008416501,0.00000547169],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002872472,0.0000876316,0.01116952,0.0004168408,0.00005077448,0.0004837836,0.0001903528,0.03927127,0.9233244,0.007693172,0.0003116934,0.01671327],"study_design_scores_gemma":[0.0001261653,0.0007912942,0.1378183,0.00008022485,0.0002354796,0.001774196,0.0006903443,0.5015176,0.3230675,0.02010305,0.01368007,0.00011589],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9887527,0.0009134847,0.009052245,0.00009803416,0.00001156237,0.00000780129,0.0001588112,0.00004292068,0.000962418],"genre_scores_gemma":[0.9951208,0.0004789408,0.003918216,0.0000142306,0.000005465803,0.000006788162,0.0003072214,0.000006354705,0.0001420426],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001158445,"threshold_uncertainty_score":0,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02094706498659729,"score_gpt":0.2479495953593082,"score_spread":0.227002530372711,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}