{"id":"W2045941212","doi":"10.1006/abbi.1999.1656","title":"Cystic Fibrosis Transmembrane Conductance Regulator: The Purified NBF1+R Protein Interacts with the Purified NBF2 Domain to Form a Stable NBF1+R/NBF2 Complex while Inducing a Conformational Change Transmitted to the C-Terminal Region","year":2000,"lang":"en","type":"article","venue":"Archives of Biochemistry and Biophysics","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Hospital for Sick Children","keywords":"Cystic fibrosis transmembrane conductance regulator; Proteolysis; Chemistry; Trypsin; Biochemistry; Transmembrane domain; Amino acid; Fusion protein; Molecular biology; Biophysics; Biology; Recombinant DNA; Gene; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005328567,0.0004609779,0.0003632448,0.0002502412,0.0003540905,0.0004091591,0.0004160651,0.0005083077,0.001596553],"category_scores_gemma":[0.0004320897,0.0002099279,0.0003782791,0.0002762853,0.0003226517,0.0003780015,0.000339735,0.0008026042,0.0008677742],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009891669,"about_ca_system_score_gemma":0.0003416232,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001690424,"about_ca_topic_score_gemma":0.001913032,"domain_scores_codex":[0.9997707,0.00003486081,0.00001531818,0.00005910556,0.00005237261,0.00006759168],"domain_scores_gemma":[0.9997678,0.0000599659,0.00003944149,0.00003984218,0.00002800896,0.0000649033],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007933916,0.00002061302,0.0002128924,0.00003053015,0.00001057553,0.00006073291,0.00002063043,0.00002774193,0.9990502,0.00008998737,0.00009047158,0.0003063522],"study_design_scores_gemma":[0.00004729537,0.00006380033,0.004883631,0.00000977067,0.00002106509,0.0005523094,0.00002334444,0.0008459319,0.9905896,0.00006203468,0.00289384,0.000007274156],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911447,0.002702063,0.003701266,0.0004109986,0.00007659745,0.00003909671,0.0003222128,0.0000994703,0.001503669],"genre_scores_gemma":[0.9877568,0.0008676659,0.004159188,0.0002271243,0.0000470813,0.00004560931,0.002476632,0.00007046211,0.004349494],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001690424,"threshold_uncertainty_score":0.007176936,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02130854681341963,"score_gpt":0.250775261885738,"score_spread":0.2294667150723183,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}