{"id":"W2045943113","doi":"10.1016/j.febslet.2007.03.003","title":"Cadmium activates CaMK‐II and initiates CaMK‐II‐dependent apoptosis in mesangial cells","year":2007,"lang":"en","type":"article","venue":"FEBS Letters","topic":"Heavy Metal Exposure and Toxicity","field":"Environmental Science","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; University of Toronto","funders":"","keywords":"Apoptosis; MAPK/ERK pathway; CAMK; Cell biology; Programmed cell death; Chemistry; Kinase; Protein kinase A; Phosphorylation; Cadmium; Mesangial cell; Calmodulin; Molecular biology; Biology; Biochemistry; In vitro; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005813255,0.0002144907,0.0002253956,0.00008847839,0.0002234312,0.00003074279,0.0001869275,0.0001145389,0.000433051],"category_scores_gemma":[0.0000366353,0.0001977973,0.00005891503,0.0002323165,0.0001708559,0.0003131902,0.0003146288,0.0002600695,0.0001299486],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001817065,"about_ca_system_score_gemma":0.000008558231,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002746404,"about_ca_topic_score_gemma":0.001013254,"domain_scores_codex":[0.9983073,0.00006721019,0.0003020303,0.0004105966,0.0003517891,0.0005610233],"domain_scores_gemma":[0.9994221,0.0001044592,0.00007495548,0.0002050992,0.000003474235,0.000189864],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004734145,0.0001171227,0.04313545,0.000009311811,0.00001581842,0.00005086212,0.001639819,0.0001032192,0.950919,0.00001726244,0.002040185,0.001904567],"study_design_scores_gemma":[0.0004941784,0.000114137,0.1056695,0.00001421392,0.00001486484,0.000008807781,0.0001550219,0.00001924866,0.8875727,0.00004711555,0.005574181,0.0003160489],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940855,0.00002748788,0.00009975756,0.001952513,0.0002801892,0.0002099906,0.000009844071,0.00003855447,0.003296187],"genre_scores_gemma":[0.995129,0.00001549077,0.0004115984,0.004062893,0.000108691,0.00000953545,0.000004934603,0.00001924324,0.0002385938],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06334636,"threshold_uncertainty_score":0.8065941,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008576428962134449,"score_gpt":0.2186735662262886,"score_spread":0.2100971372641541,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}