{"id":"W2045943113","doi":"10.1016/j.febslet.2007.03.003","title":"Cadmium activates CaMK‐II and initiates CaMK‐II‐dependent apoptosis in mesangial cells","year":2007,"lang":"en","type":"article","venue":"FEBS Letters","topic":"Heavy Metal Exposure and Toxicity","field":"Environmental Science","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; University of Toronto","funders":"","keywords":"Apoptosis; MAPK/ERK pathway; CAMK; Cell biology; Programmed cell death; Chemistry; Kinase; Protein kinase A; Phosphorylation; Cadmium; Mesangial cell; Calmodulin; Molecular biology; Biology; Biochemistry; In vitro; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008056821,0.0002602735,0.0001941091,0.0001593565,0.0001494604,0.0001986786,0.00008749991,0.0001595723,0.0009223181],"category_scores_gemma":[0.0001167209,0.0001049569,0.0001554434,0.000136943,0.0001592663,0.0001431196,0.0001652204,0.0003314451,0.000356258],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002903194,"about_ca_system_score_gemma":0.0001471298,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006896385,"about_ca_topic_score_gemma":0.001465989,"domain_scores_codex":[0.999903,0.00001423266,0.000007243589,0.00001424621,0.00003437455,0.00002698068],"domain_scores_gemma":[0.9999453,0.00001037031,0.00001132904,0.00000764275,0.00001108801,0.00001430203],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001111706,0.00001198641,0.0003558222,0.0000282729,0.000003055678,0.00004878006,0.0000102037,0.00002490211,0.9987833,0.00002474563,0.00003319884,0.0005644508],"study_design_scores_gemma":[0.00002695137,0.0001442788,0.01846648,0.000005551513,0.000008330383,0.000244766,0.00004026196,0.0006251176,0.9786258,0.0000700183,0.001737674,0.000004811248],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930347,0.002424238,0.002129481,0.000142211,0.00004272618,0.00001839594,0.0003433628,0.00005490347,0.001809984],"genre_scores_gemma":[0.9945471,0.001125143,0.001133568,0.00006445211,0.00001276529,0.00002163585,0.0003995771,0.000005553642,0.002690244],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009223181,"threshold_uncertainty_score":0.003085494,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008576428962134449,"score_gpt":0.2186735662262886,"score_spread":0.2100971372641541,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}