{"id":"W2045962653","doi":"10.1016/j.bmc.2006.07.047","title":"Synthesis and biological evaluation of a novel class of rofecoxib analogues as dual inhibitors of cyclooxygenases (COXs) and lipoxygenases (LOXs)","year":2006,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Chemistry; Rofecoxib; Stereochemistry; Arachidonate 5-lipoxygenase; Lipoxygenase; Enzyme inhibitor; Cyclooxygenase; Celecoxib; In vivo; IC50; Moiety; Nordihydroguaiaretic acid; Pharmacology; Arachidonic acid; Enzyme; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001948206,0.0003203365,0.0004539867,0.00024471,0.0002320864,0.0002641076,0.0003279705,0.0003232127,0.002222813],"category_scores_gemma":[0.0001239363,0.00013178,0.0002203165,0.0001589762,0.0001630823,0.000265071,0.000128334,0.0003428397,0.0003769723],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001908305,"about_ca_system_score_gemma":0.0003080428,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006108409,"about_ca_topic_score_gemma":0.001141136,"domain_scores_codex":[0.9999293,0.00001059577,0.00000778815,0.00001225007,0.00001295046,0.00002714368],"domain_scores_gemma":[0.9999551,0.000004651009,0.000009041643,0.000005791698,0.000009315828,0.00001610197],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002120675,0.0009361387,0.0003113057,0.0002919475,0.00004656477,0.00085985,0.0000814556,0.001148217,0.9444223,0.0009667406,0.0007319312,0.04808287],"study_design_scores_gemma":[0.002230211,0.01885649,0.003841281,0.00005407123,0.0002205398,0.002774456,0.00006282136,0.001830286,0.9258005,0.0002407658,0.04404293,0.00004570181],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9692556,0.01310202,0.00674174,0.0003719959,0.0001601943,0.0005812214,0.001003502,0.0001283798,0.008655356],"genre_scores_gemma":[0.9807526,0.007452766,0.00531666,0.000162823,0.000061021,0.0001205538,0.001110429,0.00001146018,0.005011704],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002222813,"threshold_uncertainty_score":0.007436037,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02544732109820522,"score_gpt":0.2679062945141867,"score_spread":0.2424589734159815,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}