{"id":"W2045962653","doi":"10.1016/j.bmc.2006.07.047","title":"Synthesis and biological evaluation of a novel class of rofecoxib analogues as dual inhibitors of cyclooxygenases (COXs) and lipoxygenases (LOXs)","year":2006,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Chemistry; Rofecoxib; Stereochemistry; Arachidonate 5-lipoxygenase; Lipoxygenase; Enzyme inhibitor; Cyclooxygenase; Celecoxib; In vivo; IC50; Moiety; Nordihydroguaiaretic acid; Pharmacology; Arachidonic acid; Enzyme; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000997587,0.0002399483,0.0007039555,0.00009266531,0.00003588085,0.000003268275,0.00006652995,0.0002765621,0.0001628515],"category_scores_gemma":[0.001819779,0.0001823027,0.00008973025,0.0002185425,0.0006011446,0.00003971083,0.00005907408,0.0001492126,9.159012e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004920272,"about_ca_system_score_gemma":0.0002782485,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002543518,"about_ca_topic_score_gemma":0.00001159201,"domain_scores_codex":[0.9980405,0.00006776539,0.0006596185,0.000328331,0.0006831331,0.0002206697],"domain_scores_gemma":[0.9984576,0.0004179969,0.0004055607,0.0002411783,0.0003183797,0.0001592604],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002411477,0.0003206726,0.02589085,0.001006755,0.00009336445,0.000015755,0.0001087813,8.685628e-7,0.9705024,0.00003559708,0.0002358702,0.001547919],"study_design_scores_gemma":[0.002011644,0.0003323717,0.08140165,0.0006549984,0.0005350375,0.0001822117,0.0005520895,0.000152153,0.9139182,0.00005044121,0.00006594371,0.0001432488],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994671,0.004212182,0.000006438431,0.0001071315,0.00007406931,0.0002900669,0.00005237877,0.00002170512,0.0005650087],"genre_scores_gemma":[0.9991538,0.0002243957,0.0000983707,0.0000234687,0.0003956491,0.00001637021,0.00004651105,0.00001903358,0.00002241596],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05658421,"threshold_uncertainty_score":0.7434087,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02544732109820522,"score_gpt":0.2679062945141867,"score_spread":0.2424589734159815,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}