{"id":"W2045972594","doi":"10.1016/j.bmcl.2014.05.090","title":"Base-dependent formation of cis and trans olefins and their application in the synthesis of 5-oxo-ETE receptor antagonists","year":2014,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Synthetic Organic Chemistry Methods","field":"Chemistry","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Christie (Canada)","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; National Science Foundation","keywords":"Chemistry; Alkyl; Stereochemistry; Double bond; Base (topology); Receptor; Chemical synthesis; Side chain; Combinatorial chemistry; Biochemistry; In vitro; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001025132,0.0002738542,0.000433869,0.00003249639,0.00005580083,0.00001366962,0.0003765468,0.0001860062,0.0001910359],"category_scores_gemma":[0.0004708223,0.0002094835,0.0000634332,0.0001731123,0.0003681687,0.0000617282,0.00005114109,0.0002636671,9.792039e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007467912,"about_ca_system_score_gemma":0.00003417686,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005565185,"about_ca_topic_score_gemma":0.000004870211,"domain_scores_codex":[0.9983261,0.00007783843,0.0006068681,0.0003823223,0.0003570204,0.0002498182],"domain_scores_gemma":[0.998172,0.0007805419,0.0003494776,0.0005655465,0.00004064792,0.00009177976],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004903136,0.00005662972,0.0005730587,0.001126062,0.00002190002,9.643188e-7,0.00113895,3.655293e-7,0.9857491,0.000004783236,0.00006738873,0.01121183],"study_design_scores_gemma":[0.0005930332,0.00001156863,0.0002728017,0.0002355873,0.00007336322,0.0001104018,0.002022801,0.0002513472,0.9956471,0.00003138587,0.0005641416,0.0001864181],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896758,0.0002422282,0.005311828,0.003839786,0.0000235848,0.0001136151,0.00005810252,0.00003048113,0.000704609],"genre_scores_gemma":[0.9989163,0.000137806,0.0005495301,0.0001544884,0.0001494309,0.00002851126,0.00002434793,0.00002963701,0.000009907999],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01102541,"threshold_uncertainty_score":0.8542491,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009484103499594195,"score_gpt":0.2191721614488321,"score_spread":0.2096880579492379,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}