{"id":"W2046002103","doi":"10.1038/nature04105","title":"Intrinsic dynamics of an enzyme underlies catalysis","year":2005,"lang":"en","type":"article","venue":"Nature","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1114,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; National Institutes of Health; Vetenskapsrådet; National High Magnetic Field Laboratory","keywords":"Enzyme catalysis; Chemistry; Protein dynamics; Catalysis; Enzyme; Function (biology); Cypa; Protein structure; Isomerase; Active site; Molecular dynamics; Protein engineering; Biophysics; Stereochemistry; Cyclophilin A; Computational chemistry; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004836684631991604,"score_gpt":0.2499587949413852,"score_spread":0.2451221103093936,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}