{"id":"W2046012592","doi":"10.1021/id5000212","title":"Chemical Genomics-Based Antifungal Drug Discovery: Targeting Glycosylphosphatidylinositol (GPI) Precursor Biosynthesis","year":2014,"lang":"en","type":"article","venue":"ACS Infectious Diseases","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":85,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Genome Canada","keywords":"Candida albicans; Drug discovery; Biology; Antifungal drug; Computational biology; Saccharomyces cerevisiae; Phenotypic screening; Antifungal; Mutant; Synthetic lethality; Antifungal drugs; Enzyme; Model organism; Biochemistry; Microbiology; Gene; Phenotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001695659,0.0004989569,0.0002352336,0.0003520462,0.0001149829,0.000487138,0.0002131681,0.0003151982,0.001011644],"category_scores_gemma":[0.0001101032,0.0001208795,0.0001737157,0.0002252015,0.0002827624,0.0002330667,0.0003120971,0.0004934644,0.0003444155],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003701769,"about_ca_system_score_gemma":0.0002556372,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003964824,"about_ca_topic_score_gemma":0.0007650757,"domain_scores_codex":[0.9999208,0.00001319348,0.000003566685,0.00001671634,0.00003254469,0.00001312158],"domain_scores_gemma":[0.9999672,0.000004880638,0.000009796991,0.000003929524,0.000006433491,0.000007816721],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007891063,0.0000638674,0.0002400482,0.0001469263,0.00001031089,0.00009560742,0.00001090488,0.00103153,0.9781116,0.001876367,0.0003270929,0.01800676],"study_design_scores_gemma":[0.00003900483,0.000462166,0.0009518062,0.00001544055,0.0000258017,0.0002826196,0.00002144907,0.003151539,0.979874,0.0005379837,0.01462858,0.000009624919],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8588818,0.02585113,0.08671765,0.002117558,0.0002296079,0.0003883815,0.00193999,0.001318238,0.02255553],"genre_scores_gemma":[0.9381214,0.01988916,0.03367937,0.0004296533,0.00003712286,0.000101633,0.0006453349,0.00004082355,0.007055563],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001011644,"threshold_uncertainty_score":0.003384292,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00591225959439191,"score_gpt":0.2394391597903993,"score_spread":0.2335269001960074,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}