{"id":"W2046012592","doi":"10.1021/id5000212","title":"Chemical Genomics-Based Antifungal Drug Discovery: Targeting Glycosylphosphatidylinositol (GPI) Precursor Biosynthesis","year":2014,"lang":"en","type":"article","venue":"ACS Infectious Diseases","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":85,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Genome Canada","keywords":"Candida albicans; Drug discovery; Biology; Antifungal drug; Computational biology; Saccharomyces cerevisiae; Phenotypic screening; Antifungal; Mutant; Synthetic lethality; Antifungal drugs; Enzyme; Model organism; Biochemistry; Microbiology; Gene; Phenotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002753909,0.0003656846,0.0005897362,0.0001042462,0.0002540876,0.0001266777,0.0001839774,0.0001391746,0.000178417],"category_scores_gemma":[0.001887309,0.0003218776,0.0003663476,0.000264929,0.0002580587,0.0002667973,0.00007425439,0.0002572138,0.000132225],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002568068,"about_ca_system_score_gemma":0.0003101756,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007597388,"about_ca_topic_score_gemma":0.00002374805,"domain_scores_codex":[0.9977463,0.0001174382,0.0004594377,0.0006962816,0.0004281775,0.0005523202],"domain_scores_gemma":[0.998059,0.0005983703,0.0001643497,0.0006344932,0.0001689221,0.000374895],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006627274,0.00101319,0.9268252,0.0003825509,0.0001208771,0.0000216891,0.00005639565,0.00002709255,0.06155356,0.0003876382,0.005084237,0.003864831],"study_design_scores_gemma":[0.004213066,0.0004451755,0.3964198,0.0004874081,0.001182993,0.00001686399,0.0001544466,0.001875114,0.5840403,0.0009436872,0.009038283,0.001182856],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945042,0.0009277211,0.001203239,0.0002994509,0.0002993119,0.0005299745,0.0001101277,0.000365867,0.001760171],"genre_scores_gemma":[0.99776,0.00007858795,0.000221323,0.0008408806,0.0005375484,0.00004643869,0.0001421655,0.00006390104,0.0003091526],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5304053,"threshold_uncertainty_score":0.9999233,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00591225959439191,"score_gpt":0.2394391597903993,"score_spread":0.2335269001960074,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}