{"id":"W2046025486","doi":"10.1074/jbc.m504482200","title":"Arrest-defective-1 Protein, an Acetyltransferase, Does Not Alter Stability of Hypoxia-inducible Factor (HIF)-1α and Is Not Induced by Hypoxia or HIF","year":2005,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":98,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôtel-Dieu de Québec","funders":"Canadian Institutes of Health Research; Centre National de la Recherche Scientifique; National Health Research Institutes; Institut National de la Santé et de la Recherche Médicale","keywords":"Biology; Gene silencing; HeLa; Cell biology; HEK 293 cells; Cell culture; Hypoxia-inducible factors; Post-translational regulation; RNA interference; Hypoxia-Inducible Factor 1; Molecular biology; Regulation of gene expression; RNA; Gene; Phosphorylation; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001117394,0.0004017914,0.0003490143,0.0002067782,0.0001704864,0.000271626,0.0003211284,0.0003138695,0.001418151],"category_scores_gemma":[0.0001231349,0.0001525961,0.0003036309,0.0001880302,0.0002788037,0.0001712677,0.0001321199,0.0005468479,0.000732451],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003809685,"about_ca_system_score_gemma":0.0002606105,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009368602,"about_ca_topic_score_gemma":0.001247314,"domain_scores_codex":[0.9998189,0.00001813227,0.00001793869,0.00006056271,0.00005848404,0.00002593549],"domain_scores_gemma":[0.999855,0.00001865367,0.00005294957,0.00002666721,0.00001526697,0.00003138876],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006115911,0.00001958924,0.0001115102,0.00002589612,0.000008002308,0.00003656619,0.000006860271,0.00002449129,0.9988757,0.0001142221,0.0000721168,0.0006437884],"study_design_scores_gemma":[0.00002451246,0.0002219795,0.003430198,0.000005582006,0.00002424773,0.0005926982,0.00001274567,0.0007571009,0.9830256,0.00004076728,0.01185766,0.000006946799],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9797536,0.004239281,0.00870691,0.0003150334,0.0002048469,0.00008372917,0.00298496,0.0003433973,0.00336823],"genre_scores_gemma":[0.9715082,0.0019959,0.006093331,0.0001162074,0.00002577812,0.00009111089,0.007830026,0.0001247232,0.01221462],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001418151,"threshold_uncertainty_score":0.004744172,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03119352457908848,"score_gpt":0.2745910367571683,"score_spread":0.2433975121780799,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}