{"id":"W2046025486","doi":"10.1074/jbc.m504482200","title":"Arrest-defective-1 Protein, an Acetyltransferase, Does Not Alter Stability of Hypoxia-inducible Factor (HIF)-1α and Is Not Induced by Hypoxia or HIF","year":2005,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":98,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôtel-Dieu de Québec","funders":"Canadian Institutes of Health Research; Centre National de la Recherche Scientifique; National Health Research Institutes; Institut National de la Santé et de la Recherche Médicale","keywords":"Biology; Gene silencing; HeLa; Cell biology; HEK 293 cells; Cell culture; Hypoxia-inducible factors; Post-translational regulation; RNA interference; Hypoxia-Inducible Factor 1; Molecular biology; Regulation of gene expression; RNA; Gene; Phosphorylation; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004477668,0.0003668864,0.0006448018,0.00002975998,0.00009281823,0.00003730609,0.0003762498,0.0006161686,0.0003631596],"category_scores_gemma":[0.0003760681,0.0002247884,0.0002738611,0.0001126057,0.0002823755,0.0000321297,0.0001021967,0.0004900544,0.000001249406],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004333617,"about_ca_system_score_gemma":0.0002008753,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000184273,"about_ca_topic_score_gemma":0.00000856748,"domain_scores_codex":[0.9978411,0.0001223447,0.0007594803,0.0005745573,0.0002949083,0.000407566],"domain_scores_gemma":[0.998421,0.00005581278,0.0004209751,0.0004304679,0.000300301,0.0003714543],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001514008,0.0003927044,0.0005811404,0.00007709495,0.0001118023,0.000002326281,0.00007125525,6.82839e-7,0.9902752,0.000001360143,0.0002823678,0.006690044],"study_design_scores_gemma":[0.001523881,0.0008323125,0.003647147,0.00003077025,0.00004311071,0.00005848865,0.0001027135,0.000002475914,0.9825792,0.00003846587,0.01081012,0.0003312567],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970628,0.001387793,0.0000906416,0.0004671221,0.0002110221,0.0002525467,0.0004135357,0.00001112232,0.0001034315],"genre_scores_gemma":[0.9960831,0.000994204,0.0005932441,0.00043562,0.001685829,0.00001497044,0.00002848862,0.00002382953,0.0001406897],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01052776,"threshold_uncertainty_score":0.9166604,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03119352457908848,"score_gpt":0.2745910367571683,"score_spread":0.2433975121780799,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}