{"id":"W2046110239","doi":"10.1093/brain/awu355","title":"Neuroinflammation, mitochondrial defects and neurodegeneration in mucopolysaccharidosis III type C mouse model","year":2015,"lang":"en","type":"article","venue":"Brain","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":145,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; Montreal Neurological Institute and Hospital; Université de Montréal","funders":"Fundação para a Ciência e a Tecnologia; Kyowa Hakko Kirin; Canadian Institutes of Health Research; Ministerstvo Zdravotnictví Ceské Republiky; Univerzita Karlova v Praze","keywords":"Mucopolysaccharidosis; Neurodegeneration; Lysosomal storage disease; Endocrinology; Microglia; Biology; Leukodystrophy; Mitochondrion; Internal medicine; Neuroinflammation; Cell biology; Immunology; Medicine; Inflammation; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001653596,0.0000995379,0.0001528074,0.0001672442,0.00003535816,0.00003377513,0.00005662522,0.00007232414,0.00001378918],"category_scores_gemma":[0.0009979313,0.0000956419,0.00002222475,0.0002632152,0.00003583943,0.000147008,0.00005060996,0.0001490206,0.00002872062],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005838924,"about_ca_system_score_gemma":0.0001963593,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001515711,"about_ca_topic_score_gemma":0.000273249,"domain_scores_codex":[0.9990127,0.00007446051,0.0001764296,0.0002429163,0.0002985926,0.0001948816],"domain_scores_gemma":[0.9994312,0.00004027456,0.00003104542,0.0001904349,0.0001306534,0.0001764217],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0009725484,0.0001630423,0.01182642,0.00005334008,0.00001155794,0.00006391572,0.001556555,0.003622439,0.9583591,0.0006643713,0.0206167,0.002090073],"study_design_scores_gemma":[0.02130008,0.001321768,0.009912499,0.00006398519,0.00005938485,0.000111732,0.0003530564,0.8235035,0.1387993,0.001549836,0.002374006,0.0006508401],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956979,0.000120021,0.0005471002,0.002512495,0.0001021799,0.0004381365,0.00000202308,0.00004629065,0.000533845],"genre_scores_gemma":[0.9960479,0.00001765979,0.000763751,0.0005619476,0.0001372103,0.00002162698,0.00002501911,0.00002541652,0.002399426],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.819881,"threshold_uncertainty_score":0.3900163,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0426041538648723,"score_gpt":0.2994676535511519,"score_spread":0.2568634996862796,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}