{"id":"W2046110239","doi":"10.1093/brain/awu355","title":"Neuroinflammation, mitochondrial defects and neurodegeneration in mucopolysaccharidosis III type C mouse model","year":2015,"lang":"en","type":"article","venue":"Brain","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":145,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; Montreal Neurological Institute and Hospital; Université de Montréal","funders":"Fundação para a Ciência e a Tecnologia; Kyowa Hakko Kirin; Canadian Institutes of Health Research; Ministerstvo Zdravotnictví Ceské Republiky; Univerzita Karlova v Praze","keywords":"Mucopolysaccharidosis; Neurodegeneration; Lysosomal storage disease; Endocrinology; Microglia; Biology; Leukodystrophy; Mitochondrion; Internal medicine; Neuroinflammation; Cell biology; Immunology; Medicine; Inflammation; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000281793,0.001204647,0.0004528193,0.001249646,0.0005015215,0.000416479,0.0003647521,0.001096102,0.002311275],"category_scores_gemma":[0.0001137312,0.0003408946,0.0004461267,0.0004448475,0.0005210827,0.0004065562,0.0003569305,0.001368959,0.000516544],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005672321,"about_ca_system_score_gemma":0.0005075799,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001265813,"about_ca_topic_score_gemma":0.001692059,"domain_scores_codex":[0.9997112,0.00004217388,0.00004053762,0.00007059631,0.00006920979,0.00006625152],"domain_scores_gemma":[0.9997507,0.00001374862,0.00008101926,0.00002270079,0.00002045509,0.0001113213],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001578931,0.0009453706,0.001583388,0.0002149546,0.00004784832,0.00236458,0.000145341,0.0002937157,0.9887437,0.0008504433,0.0004672648,0.00276445],"study_design_scores_gemma":[0.0008764922,0.007508513,0.044047,0.0002673283,0.0003237611,0.01729669,0.0005600794,0.004817194,0.906617,0.001660854,0.01594018,0.00008488576],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886756,0.00293464,0.002592878,0.0004125138,0.00009011028,0.0001670671,0.001372456,0.0002145024,0.003540095],"genre_scores_gemma":[0.9799001,0.003608918,0.00427442,0.0001902439,0.00004261334,0.000549089,0.001598378,0.00004870037,0.009787539],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002311275,"threshold_uncertainty_score":0.007732034,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0426041538648723,"score_gpt":0.2994676535511519,"score_spread":0.2568634996862796,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}