{"id":"W2046126869","doi":"10.1007/s11017-010-9170-9","title":"Statistical decisions and the interim analyses of clinical trials","year":2011,"lang":"en","type":"article","venue":"Metamedicine","topic":"Statistical Methods in Clinical Trials","field":"Mathematics","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Erasmus+; Canadian Institutes of Health Research; Erasmus Universiteit Rotterdam","keywords":"Interim; Clinical trial; Philosophy of medicine; Interim analysis; Data monitoring committee; Management science; Medicine; Engineering ethics; Computer science; Medical physics; Alternative medicine; Law; Political science; Economics; Engineering","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.3819759,0.002604957,0.007242199,0.003938913,0.001702464,0.006003326,0.004153645,0.005387924,0.004193157],"category_scores_gemma":[0.6470172,0.002439398,0.004188759,0.003304666,0.01311771,0.007547094,0.003356025,0.01440339,0.0007995341],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003830389,"about_ca_system_score_gemma":0.01048894,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001009694,"about_ca_topic_score_gemma":0.001031815,"domain_scores_codex":[0.335345,0.637073,0.009590989,0.005990697,0.01065052,0.001349811],"domain_scores_gemma":[0.1807813,0.766256,0.01552968,0.0299643,0.006087974,0.001380667],"domain_codex":"methods","domain_gemma":"methods","domain_candidate":"methods","domain_consensus":"methods","study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.006350707,0.0003635383,0.005004347,0.002751101,0.003035764,0.0006837408,0.00222141,0.02277763,0.0007401981,0.6721132,0.0170909,0.2668675],"study_design_scores_gemma":[0.0008636992,0.0009135929,0.001309335,0.000594024,0.0005226009,0.0003410938,0.0001888568,0.07355262,0.001405559,0.9125869,0.007626434,0.00009537358],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.009833828,0.005863144,0.9666101,0.01220342,0.001258601,0.0008954403,0.0003498808,0.0004038719,0.002581793],"genre_scores_gemma":[0.2205027,0.002572387,0.7636058,0.003922394,0.001954197,0.005006267,0.0003185522,0.0002917342,0.001826019],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.6180241,"threshold_uncertainty_score":0.7621337,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.975303311264481,"score_gpt":0.7753018544398078,"score_spread":0.2000014568246732,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}