{"id":"W2046155010","doi":"10.1126/science.1228633","title":"An Exon Splice Enhancer Primes IGF2:IGF2R Binding Site Structure and Function Evolution","year":2012,"lang":"en","type":"article","venue":"Science","topic":"Genetic Syndromes and Imprinting","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre","funders":"Cancer Research UK; Wellcome Trust","keywords":"Enhancer; Exon; splice; Function (biology); Genetics; Computational biology; Biology; Gene; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001274229,0.000145559,0.00009244185,0.0001479245,0.0001370722,0.0001520717,0.0001558731,0.0002972809,0.00201822],"category_scores_gemma":[0.0001397134,0.00008013552,0.00009178097,0.00009483935,0.0002012061,0.000131125,0.0001739472,0.0002549362,0.0002913901],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003073686,"about_ca_system_score_gemma":0.0001681636,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005767747,"about_ca_topic_score_gemma":0.00101443,"domain_scores_codex":[0.9999551,0.000006257519,0.000002494915,0.00001667195,0.00001019059,0.000009328647],"domain_scores_gemma":[0.9998987,0.00003465827,0.00002365187,0.00001163668,0.00001195968,0.00001955242],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000495184,0.000008854586,0.0031154,0.00001551921,0.000003411228,0.0001646661,0.00003894762,0.0001785816,0.989135,0.0008871335,0.00002708666,0.006375877],"study_design_scores_gemma":[0.00004230956,0.0003947615,0.216537,0.00002981733,0.00005369628,0.004437307,0.000191236,0.006695632,0.7521908,0.001750864,0.0176489,0.00002760966],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932192,0.0003254181,0.003857326,0.00008438437,0.00000894813,0.00000501014,0.00005938898,0.00006288737,0.002377347],"genre_scores_gemma":[0.9962354,0.0001305902,0.002189445,0.00004682437,0.00000736359,0.000002903583,0.00007588939,0.00001339868,0.001298217],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00201822,"threshold_uncertainty_score":0.006751597,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006335964942303857,"score_gpt":0.2466624120934972,"score_spread":0.2403264471511933,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}