{"id":"W2046155010","doi":"10.1126/science.1228633","title":"An Exon Splice Enhancer Primes IGF2:IGF2R Binding Site Structure and Function Evolution","year":2012,"lang":"en","type":"article","venue":"Science","topic":"Genetic Syndromes and Imprinting","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre","funders":"Cancer Research UK; Wellcome Trust","keywords":"Enhancer; Exon; splice; Function (biology); Genetics; Computational biology; Biology; Gene; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002594036,0.00007952154,0.00005126866,0.00004543426,0.000198154,0.00003594608,0.0001085977,0.00005751509,0.00001873593],"category_scores_gemma":[0.00003409856,0.00007072857,0.00001418897,0.0001575773,0.0001401628,0.00003055077,0.00008807606,0.00004315586,0.000008941418],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001713921,"about_ca_system_score_gemma":0.00004629542,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001650317,"about_ca_topic_score_gemma":0.000006364264,"domain_scores_codex":[0.9992109,0.00001555258,0.00007841508,0.000275437,0.0001334545,0.0002862393],"domain_scores_gemma":[0.9995907,0.00000231839,0.00004664289,0.0002043972,0.00004613823,0.0001098248],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00000217196,0.000008191857,0.05162484,0.000004311916,0.000001735915,2.115935e-8,0.00007381451,0.00001026091,0.9417512,0.00002158287,0.00001228527,0.006489569],"study_design_scores_gemma":[0.00007940847,0.0001138965,0.5068176,0.000005534842,0.000006458494,0.00002033088,0.0001103086,0.0001379983,0.4901985,0.00002386447,0.002384262,0.0001017958],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957144,0.001108443,0.002530906,0.0000106866,0.0003479228,0.00007100604,0.000003618581,0.000008658632,0.0002044094],"genre_scores_gemma":[0.9981204,0.00003625213,0.001466117,0.00003639626,0.0002085717,0.000002225944,0.000009616524,0.000006020286,0.0001144497],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4551928,"threshold_uncertainty_score":0.2884227,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006335964942303857,"score_gpt":0.2466624120934972,"score_spread":0.2403264471511933,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}