{"id":"W2046169416","doi":"10.1210/me.2012-1210","title":"Cardiac PI3K-Akt Impairs Insulin-Stimulated Glucose Uptake Independent of mTORC1 and GLUT4 Translocation","year":2012,"lang":"en","type":"article","venue":"Molecular Endocrinology","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research","keywords":"GLUT4; Protein kinase B; PI3K/AKT/mTOR pathway; Biology; mTORC1; Glucose uptake; Insulin; Glucose transporter; Internal medicine; Insulin receptor; Endocrinology; P70-S6 Kinase 1; AKT1; Insulin receptor substrate; Insulin resistance; Phosphorylation; Cell biology; Signal transduction; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002473711,0.0005609997,0.0003211829,0.0002823472,0.0001535781,0.0002796345,0.0003153431,0.0003519534,0.001977118],"category_scores_gemma":[0.00009729579,0.0003186043,0.0003620837,0.0001883736,0.0004402941,0.000257139,0.0002199045,0.0008224181,0.0004432089],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003376216,"about_ca_system_score_gemma":0.0004048872,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008112627,"about_ca_topic_score_gemma":0.001096998,"domain_scores_codex":[0.9997669,0.00002501537,0.00002997616,0.00005486405,0.0000628385,0.00006045149],"domain_scores_gemma":[0.9998397,0.0000145489,0.00005183825,0.00001637015,0.000007641185,0.0000698723],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004992227,0.0001023127,0.0001837239,0.00003769364,0.00001008951,0.00007693273,0.00001124905,0.00008831036,0.9978631,0.0001667018,0.0000548749,0.0009057844],"study_design_scores_gemma":[0.0002057886,0.001487577,0.01329603,0.00001319076,0.00006333648,0.0006706731,0.00004970138,0.002349993,0.9794044,0.0001632502,0.002284558,0.00001145048],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957321,0.0006967188,0.001567253,0.0001165297,0.0000484897,0.00002684831,0.000358242,0.0001602401,0.001293653],"genre_scores_gemma":[0.9920625,0.0007695183,0.001506102,0.00008811173,0.00001768745,0.00006582494,0.0005579258,0.00004643011,0.004885776],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001977118,"threshold_uncertainty_score":0.006614089,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008183271503384677,"score_gpt":0.240381249912175,"score_spread":0.2321979784087904,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}