{"id":"W2046198496","doi":"10.1128/jvi.75.23.11437-11448.2001","title":"Vaccinia Virus Infection Disarms the Mitochondrion-Mediated Pathway of the Apoptotic Cascade by Modulating the Permeability Transition Pore","year":2001,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Vaccinia; Mitochondrial permeability transition pore; Biology; Apoptosis; Virus; Mitochondrion; Cytochrome c; Cell biology; Staurosporine; Jurkat cells; Orthopoxvirus; Virology; Programmed cell death; Signal transduction; Immunology; Biochemistry; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002203062,0.0003189222,0.0002464412,0.0001506201,0.0001375865,0.0004468594,0.0001461521,0.0002664769,0.0005839741],"category_scores_gemma":[0.0002136711,0.0001212415,0.0001890745,0.0000767157,0.0002954772,0.0003701189,0.0002142907,0.0005366062,0.00022618],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003183599,"about_ca_system_score_gemma":0.0001898763,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001449507,"about_ca_topic_score_gemma":0.0001669134,"domain_scores_codex":[0.9998424,0.00003687339,0.0000162303,0.00002747218,0.0000335955,0.00004335467],"domain_scores_gemma":[0.9998662,0.00003604234,0.00003696546,0.00001864891,0.00001507765,0.0000270491],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004474512,0.00001116074,0.0001558913,0.00001618774,0.000002777544,0.00003341763,0.000007723197,0.00002131796,0.9990526,0.000194727,0.00001022494,0.0004492344],"study_design_scores_gemma":[0.0000145349,0.000224809,0.002573856,0.000004775165,0.00001124772,0.000378835,0.00002286963,0.0006335729,0.9940931,0.000172897,0.001865875,0.000003639325],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928403,0.001778965,0.004225986,0.00008301069,0.00004528298,0.00002232549,0.0001023951,0.0000511396,0.0008504924],"genre_scores_gemma":[0.9962665,0.0007335654,0.002203787,0.0000226069,0.00001117526,0.000009517466,0.0001274747,0.00001039747,0.0006149135],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005839741,"threshold_uncertainty_score":0.002309918,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005337680192088229,"score_gpt":0.2152464940654489,"score_spread":0.2099088138733607,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}