{"id":"W2046219181","doi":"10.1074/jbc.m809656200","title":"Inhibitory Mechanism of Escherichia coli RelE-RelB Toxin-Antitoxin Module Involves a Helix Displacement Near an mRNA Interferase Active Site","year":2009,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":85,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Institutes of Health","keywords":"RELB; Escherichia coli; Helix (gastropod); Biophysics; Antitoxin; Chemistry; Mutant; Cell biology; Stereochemistry; Toxin; Biology; Biochemistry; Transcription factor; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000932854,0.0003938783,0.0003408228,0.0001129898,0.0001778869,0.0001735604,0.0003035467,0.0002869364,0.0007258854],"category_scores_gemma":[0.00008871023,0.0001493238,0.0003262715,0.00006205629,0.0002389157,0.0001724406,0.0002625633,0.0004036693,0.0005844109],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002718178,"about_ca_system_score_gemma":0.0001268764,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002818741,"about_ca_topic_score_gemma":0.0002162581,"domain_scores_codex":[0.9998987,0.00001376254,0.000005467485,0.00002131767,0.00003473978,0.00002611936],"domain_scores_gemma":[0.9999343,0.000007311025,0.00002309561,0.000006242868,0.000008076285,0.00002094523],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000879307,0.00003059756,0.0005315575,0.00003429585,0.000007960512,0.0001709036,0.00001357537,0.0001655905,0.9974732,0.0001910536,0.00004480229,0.001248671],"study_design_scores_gemma":[0.00003882348,0.0003615209,0.005322017,0.000005468302,0.00001451947,0.0009039188,0.00002343667,0.002815071,0.9884387,0.0001250574,0.001941235,0.0000103787],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940841,0.0007964523,0.003946669,0.00005511224,0.00001551958,0.00002594202,0.00006586905,0.000153031,0.0008573421],"genre_scores_gemma":[0.9970382,0.0002036619,0.001645128,0.00004668538,0.000004923293,0.00001344122,0.0001463529,0.00001289036,0.0008886664],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007258854,"threshold_uncertainty_score":0.002428353,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01159826874269601,"score_gpt":0.2394000616832165,"score_spread":0.2278017929405205,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}