{"id":"W2046225958","doi":"10.1016/s1367-5931(00)00224-6","title":"The next generation of PDE4 inhibitors","year":2001,"lang":"en","type":"review","venue":"Current Opinion in Chemical Biology","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":118,"is_retracted":false,"has_abstract":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Rheumatoid arthritis; Clinical trial; Medicine; Pulmonary disease; Disease; Asthma; Pharmacology; Immunology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001825345,0.0002317511,0.0004536931,0.00006055885,0.00004425952,0.00001264957,0.0002075657,0.0004821812,0.00001049791],"category_scores_gemma":[0.0001323274,0.0001508712,0.0002469515,0.0001865721,0.0001841061,0.000002565454,0.0001256032,0.0002197182,0.000008617822],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000381261,"about_ca_system_score_gemma":0.0001119215,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002032087,"about_ca_topic_score_gemma":0.000001452781,"domain_scores_codex":[0.9985632,0.0001581665,0.0006370572,0.0003712995,0.00006754585,0.0002027421],"domain_scores_gemma":[0.9992254,0.00005811311,0.0003118038,0.0003034996,0.00005625286,0.00004488771],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001165895,0.00004749911,0.0000286327,0.0007606671,0.00002446019,2.997226e-8,0.000003483351,6.397128e-7,0.006184603,0.0001574303,0.0049405,0.9878404],"study_design_scores_gemma":[0.000158943,0.00004770063,0.000001183441,0.0007901011,0.0000179213,0.000007858049,0.000002651436,0.00001293712,0.002146813,0.00004005573,0.9966141,0.0001597178],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003404946,0.9937279,0.00007341581,0.00002919338,0.005449114,0.0002949044,0.00002208345,0.0000060094,0.00005689937],"genre_scores_gemma":[0.0002397518,0.9948988,0.00001946194,0.000005639844,0.001809306,0.00008395647,0.00288941,0.00001638658,0.00003727194],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9916736,"threshold_uncertainty_score":0.615235,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1736957818726307,"score_gpt":0.393814393047794,"score_spread":0.2201186111751633,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}