{"id":"W2046230337","doi":"10.1016/j.bmc.2011.01.014","title":"Structure–activity relationships in glycosylated 2-phenyl-indoles, 2-phenyl-benzo[b]thiophenes and 2-phenyl-benzo[b]furans as DNA binding and potential antitumor agents","year":2011,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"Alberta Glycomics Centre; University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Alberta Glycomics Centre","keywords":"Chemistry; Stereochemistry; Moiety; Cytotoxicity; Linker; DNA; Residue (chemistry); Chemical synthesis; Structure–activity relationship; Molecular model; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0005059226,0.0007019744,0.0008452169,0.00009563543,0.0004079083,0.00008494027,0.0004451209,0.0008453571,0.003736316],"category_scores_gemma":[0.0007744238,0.0005892059,0.0001258449,0.0003959438,0.0005120803,0.0002754113,0.0002899283,0.001171929,0.00001896347],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001931866,"about_ca_system_score_gemma":0.0001486307,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004603432,"about_ca_topic_score_gemma":0.00006070075,"domain_scores_codex":[0.9966024,0.0001305817,0.0006858601,0.001192911,0.0005772554,0.000810982],"domain_scores_gemma":[0.9981695,0.0002678136,0.0004087619,0.0005540527,0.00009193348,0.0005079014],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003578274,0.0002741556,0.05863613,0.0003883299,0.0001009521,0.0001952938,0.0003831612,1.816944e-7,0.937375,0.00002985901,0.00004628423,0.002212834],"study_design_scores_gemma":[0.001661103,0.00006673728,0.1330623,0.0003584139,0.000171846,0.0004229926,0.0009824341,0.0000897823,0.8615074,0.0008030847,0.0001626788,0.0007112473],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953513,0.0006233431,0.00002591162,0.0002069204,0.0001621548,0.0001919324,0.0001261326,0.0001762278,0.003136127],"genre_scores_gemma":[0.9986327,0.0003005321,0.0001591634,0.00006499779,0.0004015334,0.00001429518,0.00007398047,0.00006406523,0.0002887619],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07586761,"threshold_uncertainty_score":0.999656,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03720038079460676,"score_gpt":0.2285682117636286,"score_spread":0.1913678309690218,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}