{"id":"W2046231980","doi":"10.1038/nsmb.2414","title":"The binding of Varp to VAMP7 traps VAMP7 in a closed, fusogenically inactive conformation","year":2012,"lang":"en","type":"article","venue":"Nature Structural & Molecular Biology","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":79,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Wellcome Trust","keywords":"Chemistry; Cell biology; Biophysics; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003010553,0.0001992561,0.0002121807,0.00009353372,0.00008334564,0.000008425726,0.0002663363,0.0005945418,0.00001221238],"category_scores_gemma":[0.0001124672,0.0001459189,0.0001467218,0.0002181494,0.000109416,0.00000984219,0.00006356295,0.0003670261,0.00000359664],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003111362,"about_ca_system_score_gemma":0.00004908203,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002419275,"about_ca_topic_score_gemma":0.0000796197,"domain_scores_codex":[0.9987214,0.0001288716,0.0003543729,0.0002510604,0.0001252876,0.0004190228],"domain_scores_gemma":[0.9993505,0.00002083209,0.0001353105,0.0002857576,0.0001067706,0.0001008208],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002590151,0.00001102518,0.004656368,0.000009488608,0.00005351502,0.000001412837,0.0001679502,0.00001257889,0.9853749,0.005834231,0.00001985088,0.003599723],"study_design_scores_gemma":[0.001073224,0.0004818063,0.04255772,0.00001779538,0.00004232234,0.00004624505,0.0002379857,0.00004231751,0.9147201,0.001229185,0.03914756,0.0004038073],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877527,0.002063862,0.008692801,0.0002686208,0.0005020957,0.0003705102,0.00003619415,0.000008153776,0.0003050722],"genre_scores_gemma":[0.9973105,0.00007355848,0.0006745714,0.0003207741,0.0001226747,0.00001742765,0.001435898,0.00001620133,0.00002846141],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0706548,"threshold_uncertainty_score":0.59504,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003881014504965999,"score_gpt":0.2774017390004451,"score_spread":0.2735207244954791,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}