{"id":"W2046241355","doi":"10.1038/nchembio.693","title":"Cofactor mobility determines reaction outcome in the IMPDH and GMPR (β-α)8 barrel enzymes","year":2011,"lang":"en","type":"article","venue":"Nature Chemical Biology","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Center for Research Resources; National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Institutes of Health; National Science Foundation; Vetenskapsrådet; Stiftelsen för Strategisk Forskning; University of Illinois at Urbana-Champaign; University of Sheffield; Wellcome Trust","keywords":"Cofactor; Chemistry; Stereochemistry; IMP dehydrogenase; Guanosine monophosphate; Calicheamicin; Active site; Nucleotide; Biochemistry; Inosine monophosphate; Enzyme; Transferase; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002621661,0.0001711205,0.0001752045,0.00003216942,0.00003311584,0.000008872446,0.0003167662,0.0008994442,0.00001701815],"category_scores_gemma":[0.0004662712,0.0001085987,0.00008225915,0.00009427576,0.0002962124,0.000003327582,0.0001797821,0.0006157659,0.000004075359],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001203289,"about_ca_system_score_gemma":0.00002161732,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004416181,"about_ca_topic_score_gemma":0.00001638872,"domain_scores_codex":[0.9988273,0.0001041927,0.0002133189,0.0004619729,0.00008427601,0.0003089626],"domain_scores_gemma":[0.9994286,0.00004791137,0.0000443442,0.0003432471,0.00005396468,0.00008188495],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001347062,0.0000915479,0.02452403,0.00001530653,0.00001345699,0.000004073886,0.00003103561,2.87584e-9,0.9726377,0.0003375786,0.0002379255,0.001972615],"study_design_scores_gemma":[0.0003796888,0.0001344645,0.01811734,0.000003544006,0.000008691726,0.0000456265,0.00003192168,0.000002447177,0.9697411,0.0006325593,0.01074479,0.0001578387],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963525,0.002180728,0.00002011303,0.0003314136,0.00008474513,0.0001984689,0.00001894418,0.00001044458,0.00080267],"genre_scores_gemma":[0.998418,0.0001191654,0.0002114759,0.0009067568,0.0001327845,0.00004024796,0.000125985,0.0000107488,0.000034884],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01050687,"threshold_uncertainty_score":0.6937338,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02381125926524377,"score_gpt":0.3122787590445331,"score_spread":0.2884674997792893,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}