{"id":"W2046241355","doi":"10.1038/nchembio.693","title":"Cofactor mobility determines reaction outcome in the IMPDH and GMPR (β-α)8 barrel enzymes","year":2011,"lang":"en","type":"article","venue":"Nature Chemical Biology","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Center for Research Resources; National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Institutes of Health; National Science Foundation; Vetenskapsrådet; Stiftelsen för Strategisk Forskning; University of Illinois at Urbana-Champaign; University of Sheffield; Wellcome Trust","keywords":"Cofactor; Chemistry; Stereochemistry; IMP dehydrogenase; Guanosine monophosphate; Calicheamicin; Active site; Nucleotide; Biochemistry; Inosine monophosphate; Enzyme; Transferase; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004953565,0.000288019,0.0003276568,0.0001705401,0.0004344371,0.001077185,0.0004184746,0.0005111856,0.002576311],"category_scores_gemma":[0.001311945,0.0003151991,0.0001744056,0.0001796752,0.000462002,0.0009700227,0.0005366617,0.0006341838,0.0009755758],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005975128,"about_ca_system_score_gemma":0.0002728605,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008098053,"about_ca_topic_score_gemma":0.0007709346,"domain_scores_codex":[0.9997134,0.00004820669,0.00003089453,0.00005497675,0.00006054783,0.00009200579],"domain_scores_gemma":[0.9994106,0.0002018618,0.0001101011,0.00004178776,0.00009791879,0.0001376757],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001063167,0.00004598938,0.00147318,0.00004709445,0.000009343647,0.0002036075,0.0001735858,0.0003046168,0.9916661,0.00133674,0.0001224399,0.003554135],"study_design_scores_gemma":[0.00003120186,0.000188675,0.003716937,0.00001044969,0.00001430102,0.0002461809,0.0001863048,0.002865114,0.9911706,0.0006382278,0.0009011796,0.00003083579],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99797,0.0001709778,0.001019362,0.0000892662,0.000007915953,0.000004348705,0.00005238369,0.00002995697,0.0006556238],"genre_scores_gemma":[0.9989724,0.00007092541,0.0003905486,0.00001396744,0.000002943154,0.000003530993,0.00008360507,0.00001675749,0.0004452147],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002576311,"threshold_uncertainty_score":0.008618653,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02381125926524377,"score_gpt":0.3122787590445331,"score_spread":0.2884674997792893,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}