{"id":"W2046246297","doi":"10.1016/j.ejphar.2007.01.008","title":"Pharmacological characterization of a selective COX-2 inhibitor MF-tricyclic, [3-(3,4-difluorophenyl)-4-(4-(methylsulfonyl)phenyl)-2-(5H)-furanone], in multiple preclinical species","year":2007,"lang":"en","type":"article","venue":"European Journal of Pharmacology","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Pharmacology; Potency; In vivo; Chemistry; Cyclooxygenase; Carrageenan; In vitro; Medicine; Biochemistry; Biology; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.005079094,0.0003464484,0.00109608,0.0007226065,0.00007771513,0.00001147285,0.0003033076,0.0001600743,0.0005531694],"category_scores_gemma":[0.0008279771,0.000285907,0.000354586,0.0006551074,0.000342311,0.0002134445,0.0001137402,0.001299959,0.00004380723],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002213296,"about_ca_system_score_gemma":0.0002536894,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002247845,"about_ca_topic_score_gemma":0.00000234861,"domain_scores_codex":[0.9947976,0.001605656,0.002087252,0.0003551002,0.0005250244,0.0006293535],"domain_scores_gemma":[0.9964975,0.001108296,0.001297107,0.0001312104,0.0005639195,0.0004020158],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.008462342,0.00120732,0.04366514,0.00009894191,0.0002847004,0.003506386,0.0008034758,0.00001561567,0.9345987,0.000009412875,0.001466724,0.005881171],"study_design_scores_gemma":[0.01433202,0.003024536,0.3847205,0.0001146102,0.0003995223,0.0004659425,0.00008986954,0.0001735555,0.5886614,0.00000592243,0.007774096,0.0002380029],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933295,0.0002510401,0.001417456,0.0003707249,0.002607599,0.0007122974,0.00001401709,0.00003460487,0.001262781],"genre_scores_gemma":[0.9942567,0.00021678,0.0009086517,0.001044229,0.003362696,0.000004940287,0.00001148978,0.00006197469,0.0001325846],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3459373,"threshold_uncertainty_score":0.9999593,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0327006314542528,"score_gpt":0.3217578796407557,"score_spread":0.2890572481865029,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}