{"id":"W2046319392","doi":"10.1016/j.biotechadv.2010.07.004","title":"Phage display: Concept, innovations, applications and future","year":2010,"lang":"en","type":"review","venue":"Biotechnology Advances","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":485,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"Heart and Stroke Foundation of Canada","keywords":"Biopanning; Phage display; Peptide library; Phagemid; Computational biology; Directed evolution; Mutagenesis; Peptide; Biology; Epitope mapping; Bacteriophage; Epitope; Biochemistry; Peptide sequence; Escherichia coli; Genetics; Antibody; Gene; Mutation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008704641,0.0003111759,0.001009004,0.0003401911,0.0001943961,0.0000139217,0.0002254955,0.001156374,0.00008288105],"category_scores_gemma":[0.00004696275,0.0002128834,0.0001315255,0.0006632763,0.0008579458,0.0000628634,0.0001506923,0.001555122,0.00008416796],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002391654,"about_ca_system_score_gemma":0.000166917,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003976637,"about_ca_topic_score_gemma":0.000006891826,"domain_scores_codex":[0.9986785,0.00002505744,0.0003770299,0.0004728868,0.0001578138,0.0002887022],"domain_scores_gemma":[0.9990805,0.0001372,0.0001866954,0.000438426,0.00007045683,0.00008671018],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000005661047,0.00003838826,0.000008103562,0.003039356,0.00005617171,0.00001837123,0.000003218981,1.761583e-9,0.00001760373,0.05547638,0.0002409934,0.9410958],"study_design_scores_gemma":[0.0001366689,0.00007940626,0.000007641795,0.0006457515,0.0001699299,0.0005183399,0.00001807604,5.974091e-7,0.00004965461,0.0004066089,0.9977744,0.0001928996],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000008460855,0.9934035,0.0001354987,0.003917393,0.0001717679,0.001048777,0.0001971937,0.0001496214,0.0009678126],"genre_scores_gemma":[0.000001953823,0.9932251,0.003119581,0.0001191961,0.0009385484,0.0004082533,0.0004314442,0.00002910188,0.001726852],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9975334,"threshold_uncertainty_score":0.8919015,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02308429958997426,"score_gpt":0.3784322699059161,"score_spread":0.3553479703159418,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}