{"id":"W2046351270","doi":"10.1152/ajplung.00222.2006","title":"The reverse mode of the Na<sup>+</sup>/Ca<sup>2+</sup> exchanger provides a source of Ca<sup>2+</sup> for store refilling following agonist-induced Ca<sup>2+</sup> mobilization","year":2006,"lang":"en","type":"article","venue":"American Journal of Physiology-Lung Cellular and Molecular Physiology","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; St. Joseph’s Healthcare Hamilton","funders":"","keywords":"Chemistry; Extracellular; Biophysics; Ouabain; Endoplasmic reticulum; Intracellular; Calcium; Contraction (grammar); Agonist; Caffeine; Sodium-calcium exchanger; Receptor; Internal medicine; Endocrinology; Biochemistry; Sodium; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002982165,0.0002959238,0.000479967,0.0001741231,0.0002336114,0.0005364876,0.0004125916,0.0006041068,0.001289594],"category_scores_gemma":[0.0001860394,0.0001613414,0.0004411686,0.0001131047,0.0003621624,0.0007485118,0.0002929684,0.0004740797,0.0005246463],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002050386,"about_ca_system_score_gemma":0.0002235834,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005157694,"about_ca_topic_score_gemma":0.0008665184,"domain_scores_codex":[0.9998021,0.00001998185,0.00002260556,0.00005439661,0.00006679014,0.00003415362],"domain_scores_gemma":[0.9998605,0.00001722799,0.00003633545,0.00001992255,0.00003994274,0.00002600364],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008413506,0.000008649635,0.000480945,0.00007295378,0.000006995703,0.00008683775,0.00001845307,0.00001965018,0.9974094,0.0002021832,0.00006708797,0.001542706],"study_design_scores_gemma":[0.00004971349,0.0006035321,0.04366822,0.00003244868,0.00006779183,0.00171281,0.0001597388,0.004267137,0.9362335,0.0005038556,0.01267728,0.00002413189],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9650033,0.01508668,0.0134151,0.0007485841,0.000182279,0.00009146072,0.0004224016,0.0003154695,0.00473468],"genre_scores_gemma":[0.9873735,0.002682562,0.004487203,0.0002800049,0.00007496369,0.00003649987,0.0004885623,0.00002924161,0.004547433],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001289594,"threshold_uncertainty_score":0.004314184,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006639929870871634,"score_gpt":0.2306143061272169,"score_spread":0.2239743762563453,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}