{"id":"W2046351270","doi":"10.1152/ajplung.00222.2006","title":"The reverse mode of the Na<sup>+</sup>/Ca<sup>2+</sup> exchanger provides a source of Ca<sup>2+</sup> for store refilling following agonist-induced Ca<sup>2+</sup> mobilization","year":2006,"lang":"en","type":"article","venue":"American Journal of Physiology-Lung Cellular and Molecular Physiology","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; St. Joseph’s Healthcare Hamilton","funders":"","keywords":"Chemistry; Extracellular; Biophysics; Ouabain; Endoplasmic reticulum; Intracellular; Calcium; Contraction (grammar); Agonist; Caffeine; Sodium-calcium exchanger; Receptor; Internal medicine; Endocrinology; Biochemistry; Sodium; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007276919,0.0007308063,0.00125449,0.0002459336,0.0006232046,0.00004384804,0.0007117435,0.0004998229,0.00002266731],"category_scores_gemma":[0.0002993335,0.0005435955,0.00115757,0.0005020065,0.0009738322,0.00006022071,0.0003017394,0.0005550201,0.000003126012],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001159502,"about_ca_system_score_gemma":0.0003528259,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004411309,"about_ca_topic_score_gemma":0.000006750308,"domain_scores_codex":[0.9953102,0.0009656132,0.001401756,0.0009447643,0.000486413,0.0008912553],"domain_scores_gemma":[0.9963908,0.0002107635,0.001498194,0.0009211651,0.0007674643,0.0002115727],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0007472979,0.0001688261,0.00006046812,0.0001173047,0.0004120124,0.000003723787,0.001043837,0.3942212,0.6013787,0.00004985763,0.001007577,0.0007891917],"study_design_scores_gemma":[0.004065884,0.003667798,0.0002771888,0.0002862735,0.0008538838,0.0001046151,0.009990799,0.690536,0.2743121,0.0008302522,0.01395557,0.001119576],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9865714,0.00128851,0.01021483,0.0004753376,0.0002425667,0.001073888,0.00006976487,0.00002191064,0.00004177094],"genre_scores_gemma":[0.9965316,0.0002322652,0.0006767518,0.0006866665,0.000926239,0.0001118729,0.0004149223,0.0001262555,0.000293436],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3270665,"threshold_uncertainty_score":0.9997016,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006639929870871634,"score_gpt":0.2306143061272169,"score_spread":0.2239743762563453,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}