{"id":"W2046356989","doi":"10.1002/art.20809","title":"Oral treatment with PD‐0200347, an α<sub>2</sub>δ ligand, reduces the development of experimental osteoarthritis by inhibiting metalloproteinases and inducible nitric oxide synthase gene expression and synthesis in cartilage chondrocytes","year":2005,"lang":"en","type":"article","venue":"Arthritis & Rheumatism","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Osteoarthritis; Cartilage; Nitric oxide synthase; Matrix metalloproteinase; Nitric oxide; Chondrocyte; Medicine; Aggrecan; Endocrinology; Internal medicine; Pathology; Chemistry; Pharmacology; Anatomy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002899279,0.0004684504,0.0007642889,0.0002342806,0.0003485894,0.00008644844,0.00008023105,0.0001394484,0.00002910044],"category_scores_gemma":[0.00005127925,0.0003450724,0.00006082033,0.000235937,0.0002321563,0.0005798748,0.00008072426,0.0001425378,0.000005220845],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001289759,"about_ca_system_score_gemma":0.0001375098,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001145526,"about_ca_topic_score_gemma":0.0008502677,"domain_scores_codex":[0.9976019,0.000141832,0.0007097897,0.0006497825,0.0004031149,0.0004936426],"domain_scores_gemma":[0.9989933,0.0001440212,0.0002366904,0.000292471,0.0000544406,0.0002790249],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001776915,0.0004732665,0.000482419,0.00001709796,0.0000237198,0.00006021175,0.001868343,6.04307e-7,0.6491289,0.000008435964,0.000005433617,0.3477539],"study_design_scores_gemma":[0.0076852,0.002322424,0.0004839924,0.002787874,0.00006377577,0.000502286,0.00304191,0.000009450569,0.9826688,0.00001305435,0.00006847309,0.000352772],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9564305,0.04202819,0.00001319314,0.00009269947,0.00002262709,0.00123493,0.0000485543,0.00006322633,0.00006608554],"genre_scores_gemma":[0.983175,0.004149491,0.01165394,0.00003307359,0.00002542912,0.0008126184,0.00006604086,0.00006110458,0.00002331609],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3474011,"threshold_uncertainty_score":0.9999001,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01326525638818944,"score_gpt":0.2329020922110789,"score_spread":0.2196368358228894,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}