{"id":"W2046388483","doi":"10.1016/j.jmb.2012.05.007","title":"High Levels of Wild-Type BRCA2 Suppress Homologous Recombination","year":2012,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Guelph","funders":"Canadian Institutes of Health Research","keywords":"RAD51; Homologous recombination; BRCA2 Protein; Recombination; Biology; Molecular biology; Non-allelic homologous recombination; FLP-FRT recombination; Non-homologous end joining; Homologous chromosome; Genetic recombination; Small interfering RNA; DNA repair; Gene; RNA; Cell biology; Genetics; Mutation; Germline mutation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003885238,0.001063929,0.0007126446,0.0009976028,0.0003816854,0.001132988,0.000859975,0.001058406,0.004904859],"category_scores_gemma":[0.0004327488,0.000530227,0.000553257,0.0006081687,0.000842839,0.0004173524,0.0007808814,0.001819494,0.002057127],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007069161,"about_ca_system_score_gemma":0.0003935579,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001000944,"about_ca_topic_score_gemma":0.001594711,"domain_scores_codex":[0.999235,0.0001054167,0.00009106861,0.0001649938,0.0002456075,0.0001578013],"domain_scores_gemma":[0.9992505,0.0002324222,0.0001199724,0.0001381607,0.00004370662,0.0002152758],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005592559,0.00005268409,0.00008631012,0.00002269604,0.00001043778,0.00005793245,0.00001405159,0.00006693724,0.9988366,0.0002384015,0.0001234694,0.0004344911],"study_design_scores_gemma":[0.00001886046,0.00005213166,0.0009707207,0.000003912575,0.00001275848,0.0002769351,0.00002037926,0.001074645,0.9947668,0.00010941,0.002684686,0.000008704849],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9658529,0.001696393,0.01766183,0.0006610247,0.0003458825,0.0001456059,0.003053732,0.002014309,0.008568339],"genre_scores_gemma":[0.9813384,0.0004338584,0.005465524,0.0002043508,0.00004068431,0.00009154147,0.002099843,0.0004025668,0.009923219],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004904859,"threshold_uncertainty_score":0.01640838,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01011009597076669,"score_gpt":0.3206286038310688,"score_spread":0.3105185078603022,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}