{"id":"W2046388483","doi":"10.1016/j.jmb.2012.05.007","title":"High Levels of Wild-Type BRCA2 Suppress Homologous Recombination","year":2012,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Guelph","funders":"Canadian Institutes of Health Research","keywords":"RAD51; Homologous recombination; BRCA2 Protein; Recombination; Biology; Molecular biology; Non-allelic homologous recombination; FLP-FRT recombination; Non-homologous end joining; Homologous chromosome; Genetic recombination; Small interfering RNA; DNA repair; Gene; RNA; Cell biology; Genetics; Mutation; Germline mutation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003655523,0.0001212163,0.0002403616,0.00009713605,0.00001830716,0.000003894766,0.0002001538,0.0002046859,0.0000357661],"category_scores_gemma":[0.0001890035,0.0001080063,0.0001273868,0.00008605736,0.00006123491,0.000004807791,0.00006735052,0.0001204761,0.000002150618],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001136528,"about_ca_system_score_gemma":0.00004188037,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005491901,"about_ca_topic_score_gemma":8.675814e-7,"domain_scores_codex":[0.9991006,0.0001020346,0.0003712776,0.0001093392,0.00008585386,0.0002308947],"domain_scores_gemma":[0.9992234,0.00001689592,0.0002483446,0.0001979333,0.0002262979,0.00008709016],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005503187,0.00007799516,0.001899399,0.0000130769,0.000115722,0.000004695267,0.00003204497,0.0003376713,0.9935383,0.0003642505,0.0002756598,0.003286199],"study_design_scores_gemma":[0.0005671087,0.0008439989,0.008763874,0.00001164854,0.00004545698,0.0002525915,0.00002351081,0.00000589709,0.9853141,0.0003456321,0.003702384,0.0001238446],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.959186,0.00449771,0.03509467,0.000100726,0.0009327575,0.00005755506,0.000009324987,0.000002856576,0.0001184234],"genre_scores_gemma":[0.994456,0.0001852624,0.004953329,0.00008387132,0.000237823,0.000001013146,0.00001847691,0.00001662309,0.00004762351],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03527,"threshold_uncertainty_score":0.440437,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01011009597076669,"score_gpt":0.3206286038310688,"score_spread":0.3105185078603022,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}