{"id":"W2046396781","doi":"10.1158/0008-5472.sabcs13-ot2-6-11","title":"Abstract OT2-6-11: PENELOPE: Phase III study evaluating palbociclib (PD-0332991), a cyclin-dependent kinase (CDK) 4/6 inhibitor in patients with hormone-receptor-positive, HER2-normal primary breast cancer with high relapse risk after neoadjuvant chemotherapy (GBG-78/BIG1-13)","year":2013,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Palbociclib; Medicine; Internal medicine; Oncology; Clinical endpoint; Breast cancer; Taxane; Letrozole; Cancer; Placebo; Hormonal therapy; Clinical trial; Tamoxifen; Metastatic breast cancer; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009985979,0.001180943,0.00121771,0.0003762265,0.0002435382,0.001219003,0.000895073,0.0009658751,0.01215046],"category_scores_gemma":[0.0005445726,0.0003446315,0.0008228084,0.000397766,0.0006518895,0.000660983,0.0002789989,0.002707139,0.001390083],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008598382,"about_ca_system_score_gemma":0.00124928,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001567638,"about_ca_topic_score_gemma":0.003082616,"domain_scores_codex":[0.9997538,0.0001107236,0.000009121687,0.00004536724,0.00002739928,0.0000535915],"domain_scores_gemma":[0.9996283,0.00005993271,0.00006887176,0.0000262327,0.00002179052,0.0001948247],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7263013,0.0570005,0.004920834,0.001846533,0.001580413,0.0003528452,0.0001311927,0.002547671,0.05310461,0.0006054919,0.01130038,0.1403083],"study_design_scores_gemma":[0.7614937,0.2167643,0.008398678,0.0001076168,0.0005090266,0.0004556147,0.00004815981,0.001106637,0.006305018,0.0002482718,0.004530983,0.00003207773],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9651648,0.007166802,0.001279212,0.000802405,0.0001894406,0.004685311,0.008288643,0.0003733913,0.01205012],"genre_scores_gemma":[0.9684769,0.004137854,0.001875305,0.001825757,0.0001732495,0.00220093,0.00908329,0.00006286859,0.01216375],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01215046,"threshold_uncertainty_score":0.04064739,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01863472530708059,"score_gpt":0.3456849310833449,"score_spread":0.3270502057762643,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}