{"id":"W2046396781","doi":"10.1158/0008-5472.sabcs13-ot2-6-11","title":"Abstract OT2-6-11: PENELOPE: Phase III study evaluating palbociclib (PD-0332991), a cyclin-dependent kinase (CDK) 4/6 inhibitor in patients with hormone-receptor-positive, HER2-normal primary breast cancer with high relapse risk after neoadjuvant chemotherapy (GBG-78/BIG1-13)","year":2013,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Palbociclib; Medicine; Internal medicine; Oncology; Clinical endpoint; Breast cancer; Taxane; Letrozole; Cancer; Placebo; Hormonal therapy; Clinical trial; Tamoxifen; Metastatic breast cancer; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001613308,0.0009629297,0.001314062,0.0006439184,0.0004744392,0.0002171383,0.0005744338,0.0002858882,0.00344651],"category_scores_gemma":[0.00006248579,0.0007172824,0.0001490465,0.001412196,0.0007001245,0.001219247,0.0002885092,0.002349162,0.0001023651],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0032001,"about_ca_system_score_gemma":0.0018903,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.03077921,"about_ca_topic_score_gemma":0.004775558,"domain_scores_codex":[0.9906913,0.0006293606,0.001151646,0.00180113,0.003696097,0.002030446],"domain_scores_gemma":[0.9949234,0.0002950098,0.000543077,0.001244074,0.002145935,0.0008484673],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.09564058,0.006303767,0.702984,0.0002626929,0.0008278097,0.0003195232,0.005561669,0.0004287838,0.01861174,0.000001605974,0.0004638137,0.1685941],"study_design_scores_gemma":[0.08217394,0.00549025,0.9041033,0.001589961,0.0001525833,0.00001966026,0.002129056,0.00004569836,0.0032051,0.00001660066,0.0001848393,0.0008890269],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9873219,0.00211696,0.00002924693,0.00131633,0.0002447575,0.00798451,0.0007410038,0.0001418901,0.0001033834],"genre_scores_gemma":[0.9886157,0.000719589,0.0006700908,0.0004596281,0.0008095187,0.007550308,0.0001583293,0.0003574581,0.0006594054],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2011193,"threshold_uncertainty_score":0.9999524,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01863472530708059,"score_gpt":0.3456849310833449,"score_spread":0.3270502057762643,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}