{"id":"W2046425140","doi":"10.1042/bj20120769","title":"Teaching an old dogma new tricks: twenty years of Shc adaptor signalling","year":2012,"lang":"en","type":"review","venue":"Biochemical Journal","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Canadian Institutes of Health Research","keywords":"Signal transducing adaptor protein; Biology; Cell biology; Phosphotyrosine-binding domain; Proto-oncogene tyrosine-protein kinase Src; Signal transduction; Signalling; SH2 domain","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001102761,0.0007610074,0.001039744,0.001682419,0.0005558218,0.001516754,0.001052469,0.001819704,0.003033612],"category_scores_gemma":[0.001464997,0.0002367038,0.0003921876,0.001470802,0.001639974,0.003564021,0.001033399,0.003684109,0.001995666],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009860608,"about_ca_system_score_gemma":0.001109209,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007189891,"about_ca_topic_score_gemma":0.0009919155,"domain_scores_codex":[0.9997017,0.0000653908,0.00003256692,0.00005113402,0.0001123433,0.00003682624],"domain_scores_gemma":[0.999338,0.0003489001,0.0000426234,0.000029991,0.0001454239,0.00009502558],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001163284,0.00006564271,0.0001714384,0.005373439,0.00005404836,0.0002829205,0.0002169864,0.0002722107,0.001578977,0.01944151,0.1042652,0.8681614],"study_design_scores_gemma":[0.000008345399,0.0000417882,0.000255429,0.001125354,0.00001562716,0.00058625,0.00007419462,0.0000433593,0.0001999428,0.005105314,0.992532,0.00001247854],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001076034,0.9959227,0.000201289,0.001923019,0.0009027777,0.000001939722,0.000007860589,0.00001073191,0.0009221319],"genre_scores_gemma":[0.001302113,0.9940351,0.0002397721,0.001472884,0.001344569,0.000005140926,0.00001982583,0.000004167745,0.00157649],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003033612,"threshold_uncertainty_score":0.01014841,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0456299787437215,"score_gpt":0.3182789245415513,"score_spread":0.2726489457978298,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}