{"id":"W2046512645","doi":"10.4161/chim.2.4.19017","title":"Mixed chimerism and split tolerance: Mechanisms and clinical correlations","year":2011,"lang":"en","type":"review","venue":"Chimerism","topic":"Organ and Tissue Transplantation Research","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Diabetes Association","keywords":"Immunology; Clonal deletion; Immunogenicity; Immune tolerance; Haematopoiesis; Sensitization; Central tolerance; Bone marrow; Peripheral tolerance; Biology; Chimera (genetics); Antigen; Medicine; Immune system; T cell; Stem cell; Genetics; Gene; T-cell receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006448028,0.0006413966,0.001156003,0.00178827,0.0002406387,0.0008837424,0.0008237153,0.001158341,0.002392594],"category_scores_gemma":[0.0009763565,0.0001801758,0.0003176614,0.00157421,0.0009995436,0.00150025,0.0005341353,0.001693968,0.001062565],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005901401,"about_ca_system_score_gemma":0.0008530416,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005299359,"about_ca_topic_score_gemma":0.0007226553,"domain_scores_codex":[0.9997688,0.00004892048,0.00003616418,0.00004333998,0.00008357356,0.00001924751],"domain_scores_gemma":[0.9995858,0.0002163834,0.00006622148,0.0000128338,0.00008066923,0.00003804452],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000104653,0.00009752162,0.0006593011,0.01062759,0.00006817671,0.001101309,0.0001156081,0.0003765846,0.002515116,0.008821334,0.01630339,0.9592094],"study_design_scores_gemma":[0.00003519734,0.0001989243,0.003655949,0.006543369,0.0001510849,0.0253873,0.0002118386,0.0002286975,0.001873897,0.01084235,0.9508289,0.00004252491],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001598003,0.9986565,0.0001828353,0.0002004966,0.00008565062,0.000002593048,0.0000041164,0.000003413455,0.0007044688],"genre_scores_gemma":[0.001792375,0.9971412,0.0002457433,0.0001852609,0.000169964,0.000006160147,0.00001026911,0.000001279317,0.00044777],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002392594,"threshold_uncertainty_score":0.00800401,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1526548425148708,"score_gpt":0.4161889485664751,"score_spread":0.2635341060516043,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}