{"id":"W2046512645","doi":"10.4161/chim.2.4.19017","title":"Mixed chimerism and split tolerance: Mechanisms and clinical correlations","year":2011,"lang":"en","type":"review","venue":"Chimerism","topic":"Organ and Tissue Transplantation Research","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Diabetes Association","keywords":"Immunology; Clonal deletion; Immunogenicity; Immune tolerance; Haematopoiesis; Sensitization; Central tolerance; Bone marrow; Peripheral tolerance; Biology; Chimera (genetics); Antigen; Medicine; Immune system; T cell; Stem cell; Genetics; Gene; T-cell receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003534204,0.0003746746,0.001614429,0.0002004888,0.0001362061,0.00003517748,0.0001093798,0.0005331788,0.0006623888],"category_scores_gemma":[0.00005661314,0.0002989695,0.000253878,0.0002079751,0.0002677948,0.00005728758,0.00005959488,0.0009749277,0.0003240156],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001544651,"about_ca_system_score_gemma":0.0002011382,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002330609,"about_ca_topic_score_gemma":0.000003613777,"domain_scores_codex":[0.9979882,0.0001767906,0.0007443526,0.0005760788,0.0002110599,0.0003034777],"domain_scores_gemma":[0.9987136,0.0002194447,0.0001964709,0.0003927919,0.00004984715,0.0004278421],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000290759,0.0001050048,0.0001243049,0.006175664,0.0003368585,0.00007885925,0.0001474824,3.905152e-9,0.000001722055,0.002751103,0.0006609046,0.989589],"study_design_scores_gemma":[0.001192346,0.0003241445,0.004760743,0.005300188,0.002427151,0.0007185712,0.00002984816,0.00001709102,0.000003425403,0.0003032238,0.9845367,0.0003865547],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002674103,0.9947319,0.0004641239,0.00008081299,0.0005698732,0.00110281,0.00006536495,0.00008029405,0.002637399],"genre_scores_gemma":[0.00008511697,0.9917115,0.003054114,0.00007225633,0.0002967424,0.0000435228,0.0002191279,0.00007839878,0.004439195],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9892024,"threshold_uncertainty_score":0.9999462,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1526548425148708,"score_gpt":0.4161889485664751,"score_spread":0.2635341060516043,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}