{"id":"W2046572727","doi":"10.1016/j.bmc.2010.11.039","title":"New imidazoline/α2-adrenoceptors affecting compounds—4(5)-(2-aminoethyl)imidazoline (dihydrohistamine) derivatives. Synthesis and receptor affinity studies","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Chemical synthesis and alkaloids","field":"Chemistry","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Imidazoline receptor; Chemistry; Agmatine; Rilmenidine; Idazoxan; Clonidine; Moxonidine; Stereochemistry; Moiety; Receptor; Pharmacology; Agonist; Biochemistry; Antagonist; Amino acid; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0005180443,0.0008428925,0.001121662,0.00005705796,0.0003902109,0.00009318786,0.0006560188,0.0006173173,0.008085364],"category_scores_gemma":[0.00429135,0.0007485906,0.0002256545,0.0003930463,0.0007545952,0.0001521664,0.0004245068,0.001413943,0.0000521574],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002252284,"about_ca_system_score_gemma":0.0002432821,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001150086,"about_ca_topic_score_gemma":0.00002822412,"domain_scores_codex":[0.9963458,0.00003199894,0.0008921952,0.001140755,0.0007066218,0.000882582],"domain_scores_gemma":[0.9960096,0.001676728,0.0004588265,0.0008065581,0.0001996669,0.0008486274],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007969948,0.0001501408,0.002519681,0.0007388229,0.0002428193,0.00001905527,0.0005317281,1.335902e-7,0.9790864,0.00001339987,0.004573992,0.01204416],"study_design_scores_gemma":[0.0009221358,0.00001937864,0.0004470511,0.0004341913,0.0002271637,0.0001355939,0.002089408,0.00002021536,0.984813,0.0001006113,0.009994726,0.0007965681],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904518,0.003065017,0.00002589115,0.001226764,0.0003737454,0.0001140867,0.0000578227,0.0003611287,0.004323802],"genre_scores_gemma":[0.9928502,0.0006057254,0.001474326,0.0001149899,0.003403512,0.00002542617,0.00006171483,0.0001240046,0.001340038],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01124759,"threshold_uncertainty_score":0.9994965,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01858756810688005,"score_gpt":0.2579197182707286,"score_spread":0.2393321501638485,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}