{"id":"W2046622062","doi":"10.1016/j.virol.2011.01.034","title":"RNA species generated in vaccinia virus infected cells activate cell type-specific MDA5 or RIG-I dependent interferon gene transcription and PKR dependent apoptosis","year":2011,"lang":"en","type":"article","venue":"Virology","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":37,"is_retracted":false,"has_abstract":false,"ca_institutions":"CancerCare Manitoba; Public Health Agency of Canada; University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; Research Manitoba; Public Health Agency; Public Health Agency of Canada; Manitoba Health Research Council","keywords":"Biology; RIG-I; MDA5; Protein kinase R; Interferon; Innate immune system; Transcription (linguistics); RNA; Virology; Cell biology; Pattern recognition receptor; RNA silencing; Interferon type I; Gene expression; Gene; Molecular biology; Signal transduction; Receptor; RNA interference; Genetics; Mitogen-activated protein kinase kinase; Protein kinase C","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005450009,0.00070957,0.0002861488,0.0004660448,0.0003038189,0.0006187948,0.0002644359,0.0007080515,0.002422571],"category_scores_gemma":[0.000319664,0.0002986373,0.0008397907,0.0001815371,0.0004008464,0.0003797687,0.0002694463,0.001389324,0.0009877698],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006821345,"about_ca_system_score_gemma":0.0002311445,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001941187,"about_ca_topic_score_gemma":0.000306877,"domain_scores_codex":[0.9995732,0.0001104959,0.00003577365,0.0000855489,0.00007653802,0.0001184913],"domain_scores_gemma":[0.9996843,0.0001193385,0.00005890177,0.0000538958,0.00003761055,0.0000459573],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008116444,0.00001622462,0.00007080768,0.00002811806,0.000007149617,0.00004045962,0.00001478141,0.00003481972,0.9990133,0.0002555272,0.00002817123,0.0004094196],"study_design_scores_gemma":[0.00001247725,0.0001583055,0.0005787002,0.000005649103,0.00001171644,0.00008276159,0.00001976874,0.0002053611,0.9979852,0.00008245293,0.0008547081,0.000002858049],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9766376,0.002714787,0.01298364,0.0002874686,0.0004624596,0.0001476173,0.0007976965,0.0001613232,0.005807385],"genre_scores_gemma":[0.9861101,0.0007514105,0.007223774,0.0001817082,0.00009091179,0.00006942015,0.001550239,0.00005609145,0.003966414],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002422571,"threshold_uncertainty_score":0.008104324,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03326501569403555,"score_gpt":0.2207270544979013,"score_spread":0.1874620388038658,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}