{"id":"W2046622062","doi":"10.1016/j.virol.2011.01.034","title":"RNA species generated in vaccinia virus infected cells activate cell type-specific MDA5 or RIG-I dependent interferon gene transcription and PKR dependent apoptosis","year":2011,"lang":"en","type":"article","venue":"Virology","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":37,"is_retracted":false,"has_abstract":false,"ca_institutions":"CancerCare Manitoba; Public Health Agency of Canada; University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; Research Manitoba; Public Health Agency; Public Health Agency of Canada; Manitoba Health Research Council","keywords":"Biology; RIG-I; MDA5; Protein kinase R; Interferon; Innate immune system; Transcription (linguistics); RNA; Virology; Cell biology; Pattern recognition receptor; RNA silencing; Interferon type I; Gene expression; Gene; Molecular biology; Signal transduction; Receptor; RNA interference; Genetics; Mitogen-activated protein kinase kinase; Protein kinase C","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.000255488,0.0003898598,0.0005575046,0.000458279,0.0001344363,0.00002442174,0.0002957183,0.0006153931,0.005256013],"category_scores_gemma":[0.00002089898,0.0003232544,0.00007813631,0.0002079924,0.0001917278,0.0001527985,0.0001361754,0.0006032363,0.0007818299],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001044818,"about_ca_system_score_gemma":0.00005595834,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004371354,"about_ca_topic_score_gemma":0.0007188207,"domain_scores_codex":[0.9973928,0.0007632707,0.0005779378,0.0005867404,0.00004511337,0.0006341503],"domain_scores_gemma":[0.9992392,0.0001091309,0.0001573046,0.0003736308,0.00007451922,0.00004620145],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0130856,0.0004429833,0.0002728214,0.00001499354,0.000121944,0.00003908623,0.001566651,0.000002968257,0.9824431,0.00004958756,0.0005343384,0.00142593],"study_design_scores_gemma":[0.002799299,0.0022789,0.02001983,0.00001586149,0.00004704836,0.0001207898,0.0002270256,0.000005590227,0.9694942,0.00001802147,0.004638023,0.0003354783],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941567,0.002456732,0.0002058226,0.00004752976,0.001635972,0.0003627007,0.00004413268,0.00009134378,0.0009991367],"genre_scores_gemma":[0.9925665,0.003290786,0.00007304412,0.0001970247,0.00003491452,0.00003396604,0.00007515412,0.00004337262,0.00368524],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.019747,"threshold_uncertainty_score":0.9999962,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03326501569403555,"score_gpt":0.2207270544979013,"score_spread":0.1874620388038658,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}