{"id":"W2046626698","doi":"10.1124/jpet.102.039099","title":"Inhibition of Epidermal Growth Factor Receptor-Mediated Signaling by “Combi-Triazene” BJ2000, a New Probe for Combi-Targeting Postulates","year":2002,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Royal Victoria Hospital; Royal Victoria Regional Health Centre","funders":"","keywords":"Autophosphorylation; Epidermal growth factor receptor; A431 cells; EGFR inhibitors; Epidermal growth factor; Sulforhodamine B; Chemistry; Growth factor receptor; Phosphorylation; Growth inhibition; ERBB3; Cancer research; Molecular biology; Biology; Cell biology; Biochemistry; Receptor; Cell growth; In vitro; Protein kinase A; Cell; Cell cycle; Cytotoxicity","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001725816,0.0002285237,0.000174763,0.0002466196,0.0001813525,0.0003197829,0.0002967884,0.0002666461,0.001644276],"category_scores_gemma":[0.000122981,0.0001342175,0.0001568297,0.0001745325,0.0003337557,0.0003021761,0.000172089,0.0008697038,0.0003203822],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002689576,"about_ca_system_score_gemma":0.0001774346,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001726868,"about_ca_topic_score_gemma":0.0004696899,"domain_scores_codex":[0.9999324,0.0000100329,0.000004197768,0.0000103174,0.00002727233,0.00001579659],"domain_scores_gemma":[0.9999385,0.00001284085,0.00001672833,0.00001191108,0.00000770785,0.00001231001],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002409065,0.00005403444,0.000118951,0.0000501501,0.000005607342,0.00008838467,0.00002535521,0.0001182287,0.9864427,0.002872248,0.000461782,0.009521547],"study_design_scores_gemma":[0.00004900159,0.0002307245,0.0003978038,0.000002558697,0.000006673728,0.000194713,0.00001149862,0.0006150973,0.992229,0.000352337,0.005905103,0.000005520292],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9502357,0.007369766,0.02263831,0.001624893,0.0002862048,0.0001096274,0.000495315,0.0007117706,0.01652837],"genre_scores_gemma":[0.9842579,0.00253296,0.007406933,0.0002897909,0.0000461535,0.00005836619,0.0002468814,0.00004154332,0.005119496],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001644276,"threshold_uncertainty_score":0.005500674,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02556158732560809,"score_gpt":0.3001871076792731,"score_spread":0.274625520353665,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}