{"id":"W2046626698","doi":"10.1124/jpet.102.039099","title":"Inhibition of Epidermal Growth Factor Receptor-Mediated Signaling by “Combi-Triazene” BJ2000, a New Probe for Combi-Targeting Postulates","year":2002,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Royal Victoria Hospital; Royal Victoria Regional Health Centre","funders":"","keywords":"Autophosphorylation; Epidermal growth factor receptor; A431 cells; EGFR inhibitors; Epidermal growth factor; Sulforhodamine B; Chemistry; Growth factor receptor; Phosphorylation; Growth inhibition; ERBB3; Cancer research; Molecular biology; Biology; Cell biology; Biochemistry; Receptor; Cell growth; In vitro; Protein kinase A; Cell; Cell cycle; Cytotoxicity","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000194375,0.0001657157,0.0002796738,0.00007340777,0.00005948458,0.00001158972,0.00009708374,0.0001617959,0.0001136771],"category_scores_gemma":[0.000008244581,0.0001551412,0.0001116822,0.00006666329,0.00006615006,0.00001567411,0.00003247813,0.0001427161,5.527655e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000363919,"about_ca_system_score_gemma":0.00004537942,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006579397,"about_ca_topic_score_gemma":5.060163e-7,"domain_scores_codex":[0.9989349,0.0000819888,0.0004908332,0.0001596683,0.0001021012,0.0002305044],"domain_scores_gemma":[0.9993604,0.00005204197,0.0003591277,0.0000458941,0.00009940541,0.00008315354],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007929443,0.0003585557,0.0002043289,0.00001922483,0.0002079037,0.000001919878,0.0005941525,0.00001124385,0.9951282,0.00003047102,0.001780599,0.0008704796],"study_design_scores_gemma":[0.004836167,0.001688535,0.00001072129,0.00001994319,0.00004763517,0.00001952228,0.0002707131,0.0002146258,0.9846929,0.0001944308,0.007848149,0.0001566157],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9768143,0.02047502,0.001354466,0.0005541705,0.0004652271,0.0002785845,0.00004016071,0.000003894029,0.00001419446],"genre_scores_gemma":[0.9949711,0.001916619,0.001335162,0.001412475,0.0002484772,0.000008277169,0.00003032377,0.00002446848,0.00005310856],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0185584,"threshold_uncertainty_score":0.6326473,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02556158732560809,"score_gpt":0.3001871076792731,"score_spread":0.274625520353665,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}