{"id":"W2046637912","doi":"10.1038/nchembio.1361","title":"Metabolic suppression identifies new antibacterial inhibitors under nutrient limitation","year":2013,"lang":"en","type":"article","venue":"Nature Chemical Biology","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":126,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research","keywords":"Metabolite; Biochemistry; Metabolomics; Metabolic pathway; Biosynthesis; Metabolism; Mechanism of action; Escherichia coli; Biology; Drug discovery; Biotin; Small molecule; Glycine; Chemistry; Amino acid; Enzyme; In vitro; Bioinformatics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001863288,0.0005863265,0.0005333692,0.0004877688,0.0002369775,0.0007090664,0.0004400518,0.0003793697,0.00178434],"category_scores_gemma":[0.0002435638,0.0002726044,0.0003111226,0.0003048498,0.000221507,0.0004055529,0.0003367264,0.0007034873,0.0004502727],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003470476,"about_ca_system_score_gemma":0.0002940553,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003907866,"about_ca_topic_score_gemma":0.001378779,"domain_scores_codex":[0.9998698,0.00001783592,0.000009734191,0.00002542588,0.00004263096,0.00003446275],"domain_scores_gemma":[0.9998714,0.00002571459,0.00003340192,0.00001228504,0.00002775369,0.00002946956],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003021709,0.00008158572,0.0003129493,0.00005933422,0.00001341352,0.00007456457,0.00001113363,0.0002334448,0.9885026,0.0002379243,0.0001798596,0.009990974],"study_design_scores_gemma":[0.00004687354,0.0007744247,0.001892618,0.00001184506,0.0000467255,0.0003885964,0.00002415733,0.001384892,0.9887103,0.0001133945,0.006594608,0.00001152066],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9728132,0.008337727,0.007367413,0.0004897109,0.0001335109,0.0001181159,0.0008958529,0.0004306254,0.009413948],"genre_scores_gemma":[0.9852249,0.004400541,0.004264699,0.000200344,0.00005175229,0.00006275173,0.001129071,0.00009318584,0.004572545],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00178434,"threshold_uncertainty_score":0.005969286,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01078337775371362,"score_gpt":0.2616047025773572,"score_spread":0.2508213248236436,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}