{"id":"W2046637912","doi":"10.1038/nchembio.1361","title":"Metabolic suppression identifies new antibacterial inhibitors under nutrient limitation","year":2013,"lang":"en","type":"article","venue":"Nature Chemical Biology","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":126,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research","keywords":"Metabolite; Biochemistry; Metabolomics; Metabolic pathway; Biosynthesis; Metabolism; Mechanism of action; Escherichia coli; Biology; Drug discovery; Biotin; Small molecule; Glycine; Chemistry; Amino acid; Enzyme; In vitro; Bioinformatics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006523664,0.0001749532,0.0003239655,0.00008251655,0.00003865823,0.00002620242,0.0001071275,0.0008283425,0.0006146422],"category_scores_gemma":[0.0003838098,0.0001100655,0.0001123933,0.0001791689,0.0001025144,0.00009421549,0.00007949463,0.0005681687,0.0001789041],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002708385,"about_ca_system_score_gemma":0.00004542188,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007729478,"about_ca_topic_score_gemma":0.000001169112,"domain_scores_codex":[0.9989565,0.00003735341,0.0002528137,0.0003859338,0.0001021605,0.0002652562],"domain_scores_gemma":[0.9993351,0.00007433915,0.00008266111,0.0002076007,0.0001484237,0.0001519283],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001060633,0.00006017837,0.0001347958,0.00002164216,0.00003591071,8.712752e-7,0.00002732107,1.240566e-8,0.9420272,0.0005486882,0.05264783,0.004389533],"study_design_scores_gemma":[0.0006340836,0.00003638219,0.002043337,0.00003623916,0.00005579769,0.00001889836,0.00001691162,0.000001474408,0.9347609,0.002227531,0.06004108,0.0001273884],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9797401,0.002256502,0.000007722765,0.01635968,0.001060651,0.000350506,0.000008685513,0.00006643197,0.0001497563],"genre_scores_gemma":[0.9942368,0.0001630561,0.0005702548,0.001753919,0.00203125,0.000001726919,0.0003133638,0.00001401269,0.0009156499],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01460577,"threshold_uncertainty_score":0.6729901,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01078337775371362,"score_gpt":0.2616047025773572,"score_spread":0.2508213248236436,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}