{"id":"W2046646964","doi":"10.3727/096368911x601000","title":"Inhibiting Matrix Metalloproteinase by Cell-Based <i>Timp-3</i> Gene Transfer Effectively Treats Acute and Chronic Ischemic Cardiomyopathy","year":2011,"lang":"en","type":"article","venue":"Cell Transplantation","topic":"Cardiac Fibrosis and Remodeling","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"Colorado State University","keywords":"Medicine; Matrix metalloproteinase; Cardiology; Ischemic cardiomyopathy; Internal medicine; Cardiac function curve; Myocardial infarction; Genetic enhancement; Heart failure; Ligation; Extracellular matrix; Gene expression; Ventricular remodeling; Ejection fraction; Biology; Gene; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000197851,0.0002784124,0.0004223424,0.0001086812,0.0001130278,0.00002133454,0.00004214804,0.0001660902,0.00002486323],"category_scores_gemma":[0.000001326215,0.0002463475,0.0002607527,0.0001440026,0.00005574308,0.0001268669,0.000004246944,0.0002028331,0.00001162518],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000726264,"about_ca_system_score_gemma":0.0000817589,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007587929,"about_ca_topic_score_gemma":0.000002938347,"domain_scores_codex":[0.9986772,0.00006588104,0.0002985461,0.0004302032,0.000223775,0.0003043835],"domain_scores_gemma":[0.9995404,0.00003817574,0.00004665476,0.0001572273,0.00005653851,0.0001609309],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004963432,0.00008738778,0.000670546,0.001162565,0.00007876385,0.00007350698,0.0008819652,0.00007528862,0.995413,0.000001190441,0.00003040412,0.00102905],"study_design_scores_gemma":[0.004750238,0.0004071206,0.001372005,0.0001974657,0.001802445,0.0001235496,0.00003888108,0.0008227142,0.9901618,0.00000290675,0.00006929006,0.0002516372],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9560438,0.003676131,0.03647585,0.00001888074,0.00006962844,0.0007911513,0.0001472978,0.00008924678,0.002688019],"genre_scores_gemma":[0.9957032,0.001345003,0.002127278,0.00005874604,0.00008712192,0.000061761,0.000419748,0.00005719559,0.0001399907],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03965936,"threshold_uncertainty_score":0.9999989,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009447962642628037,"score_gpt":0.2211396571653397,"score_spread":0.2116916945227116,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}