{"id":"W2046651743","doi":"10.1289/ehp.11807","title":"Metabolism of Polybrominated Diphenyl Ethers (PBDEs) by Human Hepatocytes <i>in Vitro</i>","year":2008,"lang":"en","type":"article","venue":"Environmental Health Perspectives","topic":"Toxic Organic Pollutants Impact","field":"Environmental Science","cited_by":245,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University; Environment and Climate Change Canada","funders":"","keywords":"Polybrominated diphenyl ethers; Metabolite; Metabolism; Diphenyl ether; Chemistry; Monooxygenase; Xenobiotic; Cytochrome P450; Biochemistry; CYP3A4; Glutathione; Toxicokinetics; In vitro; CYP1A2; Polybrominated Biphenyls; CYP2B6; Enzyme; Drug metabolism; Environmental chemistry; Pollutant; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000216607,0.0002402094,0.0001777628,0.0001071943,0.0002169576,0.000308034,0.0001223323,0.0001922992,0.001161663],"category_scores_gemma":[0.0001180255,0.0001241779,0.0002893007,0.0001837348,0.0001731615,0.000145001,0.000127904,0.0002338302,0.0007141298],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002351616,"about_ca_system_score_gemma":0.0001895832,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002466674,"about_ca_topic_score_gemma":0.002858291,"domain_scores_codex":[0.9998154,0.00005565552,0.00002329952,0.00004009749,0.00003613767,0.00002947002],"domain_scores_gemma":[0.9999015,0.00003781209,0.0000120733,0.00001623306,0.00002556023,0.000006816924],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007072376,0.0001057606,0.003370186,0.0001115465,0.00002254278,0.0001745848,0.00009860987,0.0003399914,0.9910891,0.0000717517,0.0001156225,0.003793011],"study_design_scores_gemma":[0.00002407143,0.001262424,0.01204612,0.000008320848,0.00004350123,0.0002789017,0.00008966288,0.0008332374,0.9837705,0.00004319906,0.001592429,0.000007723133],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989281,0.002249036,0.004673424,0.0001145998,0.00006043558,0.00007492693,0.0009477141,0.00003449847,0.002564547],"genre_scores_gemma":[0.9875095,0.001964677,0.005216447,0.00008674491,0.00002515258,0.00008279902,0.00178081,0.00001318193,0.003320566],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002466674,"threshold_uncertainty_score":0.004904628,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009367488794065973,"score_gpt":0.2511739703847729,"score_spread":0.2418064815907069,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}