{"id":"W2046660691","doi":"10.1007/s12575-009-9010-3","title":"A Modified Protocol for Bisulfite Genomic Sequencing of Difficult Samples","year":2009,"lang":"en","type":"article","venue":"Biological Procedures Online","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; McGill University","funders":"Directorate for Biological Sciences; McGill University; Nanyang Technological University; Cancer Research Society; Institute of Cancer Research; Institut Du Cancer de Montréal","keywords":"Bisulfite; Cytosine; Deamination; Restriction digest; DNA; genomic DNA; Restriction enzyme; Biology; Polymerase chain reaction; DNA methylation; Computational biology; Bisulfite sequencing; Molecular biology; Biochemistry; Gene; Enzyme; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002800233,0.002969153,0.002117263,0.003900297,0.001866071,0.001172843,0.003201209,0.00180511,0.02824328],"category_scores_gemma":[0.003038185,0.002232224,0.001880556,0.002572684,0.001017495,0.0009336278,0.001421989,0.00492263,0.0267706],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005829273,"about_ca_system_score_gemma":0.001786887,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001211816,"about_ca_topic_score_gemma":0.00511626,"domain_scores_codex":[0.996042,0.001038652,0.000539908,0.001055322,0.0009641777,0.0003599879],"domain_scores_gemma":[0.9982181,0.0002494292,0.00008263576,0.0009660433,0.0003810475,0.0001027399],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004765229,0.0004058001,0.0005891516,0.001396324,0.0002537161,0.0005554931,0.0004369593,0.001289953,0.8942918,0.00332398,0.01920977,0.07777052],"study_design_scores_gemma":[0.0003245761,0.001047022,0.003883703,0.0002048314,0.000384267,0.002378692,0.00008461448,0.007191713,0.4762133,0.003123111,0.5048718,0.0002923756],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"protocol","genre_scores_codex":[0.01207695,0.001645456,0.9471449,0.0002700854,0.001215598,0.008784889,0.01087489,0.00956436,0.008422836],"genre_scores_gemma":[0.01330239,0.001331275,0.9255365,0.0005048339,0.0001284052,0.01194356,0.02203672,0.001334726,0.02388172],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.02824328,"threshold_uncertainty_score":0.09448314,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08691515981385817,"score_gpt":0.3537637271344296,"score_spread":0.2668485673205714,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}