{"id":"W2046663210","doi":"10.1016/j.tox.2012.01.004","title":"An ex vivo approach to the differential parenchymal responses induced by cigarette whole smoke and its vapor phase","year":2012,"lang":"en","type":"article","venue":"Toxicology","topic":"Inhalation and Respiratory Drug Delivery","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; British American Tobacco (Canada)","funders":"China Scholarship Council; British American Tobacco","keywords":"Smoke; Particulates; Cigarette smoke; Chemistry; Gene expression; CYP1B1; Ex vivo; Inhalation exposure; Inhalation; In vivo; Alveolar macrophage; Smoke inhalation; Lung; Parenchyma; Toxicity; Gene; Cytochrome P450; Biology; Toxicology; Pathology; In vitro; Internal medicine; Medicine; Biochemistry; Macrophage; Anatomy; Genetics; Metabolism; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002842456,0.0001467215,0.0002333072,0.00009878251,0.0001466138,0.00001729209,0.00009910956,0.0001940627,0.0003415726],"category_scores_gemma":[0.00009550848,0.0000970872,0.00003692529,0.0001082867,0.00006138323,0.00009031735,0.00005054008,0.0002312092,0.00003988613],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002894404,"about_ca_system_score_gemma":0.0000587327,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004066409,"about_ca_topic_score_gemma":0.000002466891,"domain_scores_codex":[0.9987904,0.000265571,0.0002024221,0.0002293893,0.0001611054,0.0003511404],"domain_scores_gemma":[0.9992575,0.00006832457,0.00005745543,0.0002489925,0.00005285203,0.0003148433],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001098723,0.001590364,0.001651897,0.00002230742,0.00006893322,0.000009245992,0.002335162,0.000001588837,0.9728243,0.0002519829,0.0129105,0.007235027],"study_design_scores_gemma":[0.01636919,0.007707702,0.110835,0.00004524192,0.0006342206,0.0004815267,0.002359637,0.002674107,0.5663592,0.00001245745,0.2913951,0.001126623],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958373,0.0002733889,0.0001333302,0.001416557,0.0004137862,0.0004675874,0.00004225091,0.00005043066,0.001365398],"genre_scores_gemma":[0.9933147,0.000004144213,0.00002534152,0.004572833,0.000542361,0.00004625456,0.00003483991,0.00001782308,0.001441692],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4064651,"threshold_uncertainty_score":0.3959101,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06737115055572891,"score_gpt":0.3445243507721197,"score_spread":0.2771532002163908,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}