{"id":"W2046722461","doi":"10.1042/0264-6021:3530483","title":"mSiglec-E, a novel mouse CD33-related siglec (sialic acid-binding immunoglobulin-like lectin) that recruits Src homology 2 (SH2)-domain-containing protein tyrosine phosphatases SHP-1 and SHP-2","year":2001,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Biotechnology Research Institute","funders":"","keywords":"SIGLEC; Immunoreceptor tyrosine-based activation motif; Biology; Immunoglobulin superfamily; Protein tyrosine phosphatase; Immunoglobulin domain; Proto-oncogene tyrosine-protein kinase Src; SH2 domain; Molecular biology; Sialic acid; Biochemistry; Cell biology; Lectin; Tyrosine; Signal transduction; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0005392051,0.0004807953,0.0005916488,0.0003255575,0.0007629023,0.0001571957,0.0003490779,0.0007596968,0.0019],"category_scores_gemma":[0.0002997348,0.000435731,0.000245567,0.0003614592,0.000349759,0.0003815014,0.0001865945,0.001620523,0.0003279826],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000280491,"about_ca_system_score_gemma":0.0001365531,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000908401,"about_ca_topic_score_gemma":0.00000611257,"domain_scores_codex":[0.997299,0.0002697855,0.0008419587,0.00057357,0.0001207216,0.0008949313],"domain_scores_gemma":[0.9986655,0.0001481841,0.0005503286,0.0003147702,0.0001893556,0.0001318889],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002078508,0.0003052514,0.0005894401,0.00001307034,0.0003738315,0.00005797475,0.0003238241,0.000001114276,0.9839206,0.0001299728,0.01019473,0.00201162],"study_design_scores_gemma":[0.00492299,0.0007526899,0.0003979778,0.0002116175,0.0000973054,0.01025119,0.0008309817,0.00000744452,0.9106556,0.00006644157,0.07128817,0.0005176127],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.979865,0.01396713,0.0009809221,0.0006374083,0.003427347,0.0004403266,0.00001415179,0.0001433679,0.0005243673],"genre_scores_gemma":[0.9878749,0.0008188355,0.0003974433,0.0004898176,0.0001741293,0.00003809865,0.0002827572,0.00006226751,0.00986174],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07326508,"threshold_uncertainty_score":0.9998094,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02173002573800953,"score_gpt":0.2411454540149029,"score_spread":0.2194154282768934,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}