{"id":"W2046722461","doi":"10.1042/0264-6021:3530483","title":"mSiglec-E, a novel mouse CD33-related siglec (sialic acid-binding immunoglobulin-like lectin) that recruits Src homology 2 (SH2)-domain-containing protein tyrosine phosphatases SHP-1 and SHP-2","year":2001,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Biotechnology Research Institute","funders":"","keywords":"SIGLEC; Immunoreceptor tyrosine-based activation motif; Biology; Immunoglobulin superfamily; Protein tyrosine phosphatase; Immunoglobulin domain; Proto-oncogene tyrosine-protein kinase Src; SH2 domain; Molecular biology; Sialic acid; Biochemistry; Cell biology; Lectin; Tyrosine; Signal transduction; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004148811,0.00029814,0.0000975321,0.0003291621,0.0001001441,0.0002320976,0.0001535978,0.0002102695,0.000800794],"category_scores_gemma":[0.00005627891,0.00006492481,0.0001337304,0.0002209847,0.0001382106,0.0001824673,0.000180982,0.0001912954,0.0002924254],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002398387,"about_ca_system_score_gemma":0.0001219545,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002499114,"about_ca_topic_score_gemma":0.0005139346,"domain_scores_codex":[0.9999545,0.000004643738,0.000003428253,0.00001154659,0.00001548422,0.00001036744],"domain_scores_gemma":[0.9999639,0.000002901313,0.00001175928,0.000002432883,0.000004740179,0.00001423635],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004683961,0.00001826878,0.001313445,0.00003772272,0.000005932225,0.0001670154,0.00001031126,0.00007437276,0.9909917,0.0002966918,0.0002115515,0.00682627],"study_design_scores_gemma":[0.00002196088,0.0002943844,0.02835955,0.00001546148,0.00004171606,0.003375055,0.00005002228,0.002213595,0.9332052,0.0002500451,0.03215747,0.0000155657],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9856167,0.003315604,0.006766734,0.0001351508,0.00003313245,0.00004005396,0.0006951082,0.0002013664,0.003196205],"genre_scores_gemma":[0.9842839,0.002204855,0.005466801,0.0001111495,0.00002021477,0.00002662247,0.002031561,0.00001614806,0.005838764],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000800794,"threshold_uncertainty_score":0.002678931,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02173002573800953,"score_gpt":0.2411454540149029,"score_spread":0.2194154282768934,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}