{"id":"W2046724439","doi":"10.1038/nchembio.299","title":"Inactive but not inert","year":2010,"lang":"en","type":"letter","venue":"Nature Chemical Biology","topic":"Pharmaceutical and Antibiotic Environmental Impacts","field":"Environmental Science","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"","keywords":"Tetracycline; Enzyme; Antibiotics; Chemistry; Computational biology; Inert; Drug resistance; Microbiology; Biology; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["research_integrity","insufficient_payload"],"category_scores_codex":[0.00008696856,0.0004360483,0.0004319916,0.00003031076,0.00005369435,0.00001590715,0.000674208,0.008350819,0.006197651],"category_scores_gemma":[0.0001859074,0.0003236846,0.0001667697,0.0001138676,0.00112174,0.00006845753,0.0006635278,0.01570582,0.002351052],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002179493,"about_ca_system_score_gemma":0.000009847764,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000479915,"about_ca_topic_score_gemma":0.000002290684,"domain_scores_codex":[0.9979292,0.00006027856,0.0002408741,0.0007930446,0.0002597031,0.0007168589],"domain_scores_gemma":[0.9991016,0.0002128481,0.0001181074,0.0003710096,0.000004358358,0.0001921068],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001368094,0.00003355747,0.0003046646,0.000008110336,0.00001558328,0.00006093888,0.000003782993,4.451662e-8,0.5706344,0.000008574008,0.4272001,0.001716477],"study_design_scores_gemma":[0.0001471596,0.00002591612,0.0002401662,0.000006684729,0.0000228961,0.00003773427,7.739527e-7,0.000004024884,0.3899418,0.0004578977,0.6088367,0.0002783518],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.206316,0.000133337,0.000009006943,0.7432756,0.001383459,0.0003442972,0.0003051422,0.0001234153,0.04810971],"genre_scores_gemma":[0.283945,0.00003643144,0.0003648962,0.711799,0.001755511,0.000005458093,0.0004695785,0.00003426867,0.001589829],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.1816365,"threshold_uncertainty_score":0.9999215,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01239681459644903,"score_gpt":0.2818398437075694,"score_spread":0.2694430291111204,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}