{"id":"W2046724439","doi":"10.1038/nchembio.299","title":"Inactive but not inert","year":2010,"lang":"en","type":"letter","venue":"Nature Chemical Biology","topic":"Pharmaceutical and Antibiotic Environmental Impacts","field":"Environmental Science","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"","keywords":"Tetracycline; Enzyme; Antibiotics; Chemistry; Computational biology; Inert; Drug resistance; Microbiology; Biology; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001146405,0.0004500493,0.000674382,0.0002420128,0.001414324,0.001859702,0.0009605912,0.01125786,0.01007797],"category_scores_gemma":[0.004394579,0.0002542638,0.0005822623,0.0001706645,0.001775103,0.001170092,0.0009073673,0.009742432,0.005380315],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001263358,"about_ca_system_score_gemma":0.0006918955,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000708419,"about_ca_topic_score_gemma":0.001261734,"domain_scores_codex":[0.9992538,0.0001562171,0.00004764179,0.0001427482,0.0002294115,0.0001701562],"domain_scores_gemma":[0.9990641,0.0004425137,0.00006195182,0.0001219325,0.0001165513,0.0001928819],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00047456,0.0001841119,0.001265829,0.0001957603,0.00005877341,0.01053226,0.0002889835,0.00006493165,0.01450749,0.06127542,0.861548,0.04960376],"study_design_scores_gemma":[0.0001574338,0.0001842571,0.0007501311,0.00008755038,0.0000475184,0.009015886,0.0002036464,0.0001602858,0.00625337,0.03231626,0.9507929,0.00003082133],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.01630577,0.009137254,0.0012424,0.8286123,0.0291827,0.00003929365,0.0003310614,0.0002023182,0.1149469],"genre_scores_gemma":[0.1246727,0.003616015,0.001024364,0.7496533,0.01134695,0.00006841708,0.0003217398,0.00008841045,0.109208],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.01125786,"threshold_uncertainty_score":0.03371423,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01239681459644903,"score_gpt":0.2818398437075694,"score_spread":0.2694430291111204,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}