{"id":"W2046742966","doi":"10.1016/j.bmc.2009.05.027","title":"Benzhydrylquinazolinediones: Novel cytosolic phospholipase A2α inhibitors with improved physicochemical properties","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Lipophilicity; Pharmacophore; Phospholipase A2; Quinazoline; Arachidonic acid; Cytosol; Indole test; Chemical synthesis; Biological activity; Enzyme inhibitor; Biochemistry; Solubility; Combinatorial chemistry; In vitro; Enzyme; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001376941,0.0003835196,0.00029995,0.00002655061,0.000128284,0.00003519103,0.0002737365,0.000278518,0.00006590226],"category_scores_gemma":[0.0001057333,0.0003023915,0.0001122535,0.0002197117,0.0002019385,0.00001166989,0.00006960001,0.0002482485,0.00000962778],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005581184,"about_ca_system_score_gemma":0.0002526788,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001350892,"about_ca_topic_score_gemma":0.000001676996,"domain_scores_codex":[0.9982157,0.00001259209,0.0003528189,0.0006147572,0.0003496613,0.0004544302],"domain_scores_gemma":[0.9988732,0.000005115324,0.0001632566,0.0004965159,0.0001751562,0.0002867491],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003347001,0.0002210376,0.00004715935,0.00007253257,0.0000415097,0.000009574807,0.00005858963,0.000006280366,0.9977688,0.00001098101,0.0004094657,0.001019365],"study_design_scores_gemma":[0.001771287,0.0003058983,0.0001381488,0.0001808063,0.00005831444,0.0001635047,0.0001766416,0.0001301551,0.9929572,0.00001560102,0.003677247,0.0004252472],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946758,0.002099509,0.001392713,0.000861846,0.00006420891,0.0002664583,0.00001410265,0.00008127803,0.0005440677],"genre_scores_gemma":[0.9964636,0.00005296962,0.0004928082,0.0007343706,0.001614944,0.00002510566,0.0001895153,0.00004248838,0.0003842151],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004811656,"threshold_uncertainty_score":0.9999428,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009447681125863304,"score_gpt":0.2138709529279529,"score_spread":0.2044232718020896,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}