{"id":"W2046749288","doi":"10.1016/j.bbagen.2010.06.007","title":"A monovalent agonist of TrkA tyrosine kinase receptors can be converted into a bivalent antagonist","year":2010,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - General Subjects","topic":"Nerve injury and regeneration","field":"Neuroscience","cited_by":19,"is_retracted":false,"has_abstract":false,"ca_institutions":"National Research Council Canada; Biotechnology Research Institute; McGill University; Jewish General Hospital","funders":"National Institute of General Medical Sciences; National Institute of Mental Health; National Institutes of Health; Canadian Institutes of Health Research; Cancer Research Society","keywords":"Bivalent (engine); Agonist; Chemistry; Tropomyosin receptor kinase A; Receptor; Competitive antagonist; Antagonist; Linker; Tyrosine kinase; Stereochemistry; Partial agonist; Dimer; Biophysics; Biochemistry; Nerve growth factor; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001778387,0.0004029609,0.0002813873,0.000202839,0.000179622,0.0004248895,0.0004727877,0.0003444765,0.003343476],"category_scores_gemma":[0.0001881114,0.0001856519,0.0002463207,0.0001874071,0.0002158049,0.0002763707,0.0003686111,0.0007884676,0.0009271261],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002449375,"about_ca_system_score_gemma":0.0002587958,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004011581,"about_ca_topic_score_gemma":0.0003773907,"domain_scores_codex":[0.9998497,0.00001793406,0.00001225251,0.00003470781,0.00003561444,0.00004978848],"domain_scores_gemma":[0.9999174,0.00001814285,0.00001253466,0.00001120407,0.00001074366,0.0000300276],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001609983,0.00001931336,0.00003959308,0.00004189911,0.000007410614,0.00004121382,0.0000122642,0.00004140232,0.9979556,0.0004703015,0.00006330355,0.001146836],"study_design_scores_gemma":[0.00004946187,0.0003965377,0.000723491,0.0000104725,0.00003637273,0.0003091886,0.00002631689,0.0003026412,0.9893607,0.0001658721,0.008606491,0.00001267519],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9714757,0.002701116,0.01075091,0.000294777,0.0003305072,0.000139246,0.0003832112,0.000148768,0.01377579],"genre_scores_gemma":[0.9819602,0.001468588,0.004258459,0.0002199128,0.00004218595,0.000074654,0.0005286111,0.00006499675,0.01138247],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003343476,"threshold_uncertainty_score":0.01118499,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02183218267331868,"score_gpt":0.2710957259143137,"score_spread":0.249263543240995,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}