{"id":"W2046804572","doi":"10.1016/j.stem.2010.03.014","title":"Multiple Epigenetic Modifiers Induce Aggressive Viral Extinction in Extraembryonic Endoderm Stem Cells","year":2010,"lang":"en","type":"article","venue":"Cell stem cell","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lawson Health Research Institute; Children’s Health Research Institute; Western University","funders":"Canadian Institutes of Health Research","keywords":"Biology; Stem cell; Embryonic stem cell; Endoderm; Cell biology; Argonaute; Epigenetics; Epiblast; Chromatin; Genetics; Gene silencing; RNA interference; Gene; RNA; Gastrulation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001582246,0.0002911939,0.0002107345,0.00009156069,0.00007267312,0.00003614156,0.0002816718,0.0003479474,0.00003764321],"category_scores_gemma":[0.000004681978,0.0003117769,0.0001201669,0.0001105195,0.00005370155,0.00000602336,0.0001137586,0.0003662163,0.00005572358],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002541812,"about_ca_system_score_gemma":0.00008446568,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002865033,"about_ca_topic_score_gemma":0.0001558473,"domain_scores_codex":[0.9983895,0.00005336315,0.0003383849,0.0005735998,0.0001537874,0.0004913458],"domain_scores_gemma":[0.9990821,0.00002960895,0.0001523244,0.0005294374,0.00004566805,0.0001608445],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003143356,0.00009610505,0.0009461424,0.00006595856,0.000007324657,0.00001709573,0.000165937,0.004487006,0.9876494,0.000001838544,0.0001442748,0.006387531],"study_design_scores_gemma":[0.001062876,0.0001259227,0.0008474202,0.00001297917,0.00001512832,0.00001029943,0.0002642501,0.002195187,0.9890411,0.000007206209,0.006059877,0.0003576961],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906448,0.002005015,0.00349337,0.000009069037,0.00104549,0.0003681683,0.0000130586,0.00002693925,0.002394078],"genre_scores_gemma":[0.9960708,0.0002852348,0.0003990247,0.00003481562,0.0002271722,0.00004976511,0.00002793027,0.00005681641,0.002848412],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006029835,"threshold_uncertainty_score":0.9999334,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007120971652296585,"score_gpt":0.2343752499363213,"score_spread":0.2272542782840247,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}